Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Domain |
PF02518 Histidine kinase- PF00183 Hsp90 protein |
Function |
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. |
Biological Process |
GO:0001666 response to hypoxia GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006457 protein folding GO:0006470 protein dephosphorylation GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006898 receptor-mediated endocytosis GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0007015 actin filament organization GO:0010498 proteasomal protein catabolic process GO:0010921 regulation of phosphatase activity GO:0014074 response to purine-containing compound GO:0016311 dephosphorylation GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030968 endoplasmic reticulum unfolded protein response GO:0030970 retrograde protein transport, ER to cytosol GO:0031247 actin rod assembly GO:0031349 positive regulation of defense response GO:0032527 protein exit from endoplasmic reticulum GO:0033198 response to ATP GO:0034620 cellular response to unfolded protein GO:0034975 protein folding in endoplasmic reticulum GO:0034976 response to endoplasmic reticulum stress GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036293 response to decreased oxygen levels GO:0036500 ATF6-mediated unfolded protein response GO:0036503 ERAD pathway GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043666 regulation of phosphoprotein phosphatase activity GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0046683 response to organophosphorus GO:0051017 actin filament bundle assembly GO:0051208 sequestering of calcium ion GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0055074 calcium ion homeostasis GO:0061572 actin filament bundle organization GO:0070482 response to oxygen levels GO:0071318 cellular response to ATP GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:1903513 endoplasmic reticulum to cytosol transport |
Molecular Function |
GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0046790 virion binding GO:0050750 low-density lipoprotein particle receptor binding GO:0051082 unfolded protein binding GO:0070325 lipoprotein particle receptor binding |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030139 endocytic vesicle GO:0030496 midbody GO:0031983 vesicle lumen GO:0034663 endoplasmic reticulum chaperone complex GO:0042470 melanosome GO:0048770 pigment granule GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0071682 endocytic vesicle lumen |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum hsa04151 PI3K-Akt signaling pathway hsa04915 Estrogen signaling pathway hsa04918 Thyroid hormone synthesis |
Reactome |
R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-392499: Metabolism of proteins R-HSA-3000480: Scavenging by Class A Receptors R-HSA-449147: Signaling by Interleukins R-HSA-168898: Toll-Like Receptors Cascades R-HSA-1679131: Trafficking and processing of endosomal TLR R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HSP90B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HSP90B1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HSP90B1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HSP90B1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HSP90B1 in various data sets.
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Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSP90B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSP90B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSP90B1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSP90B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HSP90B1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HSP90B1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HSP90B1 |
Name | heat shock protein 90kDa beta (Grp94), member 1 |
Aliases | GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ...... |
Chromosomal Location | 12q24.2-q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HSP90B1 collected from DrugBank database. |
Details on drugs targeting HSP90B1.
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