Browse HSP90B1

Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Domain PF02518 Histidine kinase-
PF00183 Hsp90 protein
Function

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

> Gene Ontology
 
Biological Process GO:0001666 response to hypoxia
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0006457 protein folding
GO:0006470 protein dephosphorylation
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0007015 actin filament organization
GO:0010498 proteasomal protein catabolic process
GO:0010921 regulation of phosphatase activity
GO:0014074 response to purine-containing compound
GO:0016311 dephosphorylation
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
GO:0031247 actin rod assembly
GO:0031349 positive regulation of defense response
GO:0032527 protein exit from endoplasmic reticulum
GO:0033198 response to ATP
GO:0034620 cellular response to unfolded protein
GO:0034975 protein folding in endoplasmic reticulum
GO:0034976 response to endoplasmic reticulum stress
GO:0035303 regulation of dephosphorylation
GO:0035304 regulation of protein dephosphorylation
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036293 response to decreased oxygen levels
GO:0036500 ATF6-mediated unfolded protein response
GO:0036503 ERAD pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0046683 response to organophosphorus
GO:0051017 actin filament bundle assembly
GO:0051208 sequestering of calcium ion
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0055074 calcium ion homeostasis
GO:0061572 actin filament bundle organization
GO:0070482 response to oxygen levels
GO:0071318 cellular response to ATP
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:1903513 endoplasmic reticulum to cytosol transport
Molecular Function GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0046790 virion binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051082 unfolded protein binding
GO:0070325 lipoprotein particle receptor binding
Cellular Component GO:0005788 endoplasmic reticulum lumen
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
GO:0030139 endocytic vesicle
GO:0030496 midbody
GO:0031983 vesicle lumen
GO:0034663 endoplasmic reticulum chaperone complex
GO:0042470 melanosome
GO:0048770 pigment granule
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0071682 endocytic vesicle lumen
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
hsa04151 PI3K-Akt signaling pathway
hsa04915 Estrogen signaling pathway
hsa04918 Thyroid hormone synthesis
Reactome R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-392499: Metabolism of proteins
R-HSA-3000480: Scavenging by Class A Receptors
R-HSA-449147: Signaling by Interleukins
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-1679131: Trafficking and processing of endosomal TLR
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HSP90B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between HSP90B1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27364122Melanoma; Colorectal carcinomaPromote immunity (T cell function)A cell-based vaccine cosecreting gp96-Ig and Fc-OX40L led to even more pronounced tumor control, complete tumor rejection, and increased tumor antigen-specific T-cell proliferation, including in tumor-infiltrating lymphocytes, as compared with combinations of gp96-Ig vaccine and OX40 antibodies, in mice with established melanoma or colorectal carcinoma.
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HSP90B1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 4.82; FDR: 0.005 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HSP90B1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3320.196
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6120.873
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1320.963
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0730.814
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2070.94
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0960.978
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0270.967
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4060.885
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4270.889
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6640.821
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9990.825
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1420.0887
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HSP90B1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSP90B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSP90B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSP90B1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSP90B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HSP90B1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HSP90B1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHSP90B1
Nameheat shock protein 90kDa beta (Grp94), member 1
Aliases GP96; GRP94; tumor rejection antigen (gp96) 1; HEL-S-125m; HEL35; 94 kDa glucose-regulated protein; endothel ......
Chromosomal Location12q24.2-q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HSP90B1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HSP90B1.
ID Name Drug Type Targets #Targets
DB00615RifabutinSmall MoleculeHSP90AA1, HSP90B12
DB021032-ChlorodideoxyadenosineSmall MoleculeHSP90B11
DB02424GeldanamycinSmall MoleculeHSP90AA1, HSP90AB1, HSP90B13
DB02935DiglymeSmall MoleculeHSP90B11
DB03719N-Ethyl-5'-Carboxamido AdenosineSmall MoleculeHSP90B11
DB03758RadicicolSmall MoleculeDLAT, HSP90AB1, HSP90B1, PDK34
DB08464METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATESmall MoleculeHSP90AB1, HSP90B12
DB084652-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATESmall MoleculeHSP90AB1, HSP90B12
DB09130CopperSmall MoleculeA1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......141