Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Secreted Note=Translocates to nuclear foci during heat shock. |
Domain |
PF00525 Alpha crystallin A chain PF00011 Hsp20/alpha crystallin family |
Function |
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. |
Biological Process |
GO:0003012 muscle system process GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0044057 regulation of system process GO:0090257 regulation of muscle system process |
Molecular Function |
GO:0005212 structural constituent of eye lens |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HSPB6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HSPB6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HSPB6 in various data sets.
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Points in the above scatter plot represent the mutation difference of HSPB6 in various data sets.
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Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSPB6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSPB6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSPB6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSPB6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HSPB6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HSPB6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HSPB6 |
Name | heat shock protein, alpha-crystallin-related, B6 |
Aliases | FLJ32389; Hsp20; PPP1R91; protein phosphatase 1, regulatory subunit 91; HEL55; epididymis luminal protein 55 ...... |
Chromosomal Location | 19q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HSPB6 collected from DrugBank database. |
There is no record. |