Summary | |
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Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Nucleus, Cajal body Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
Domain |
PF00011 Hsp20/alpha crystallin family |
Function |
- |
Biological Process |
GO:0003013 circulatory system process GO:0003015 heart process GO:0006986 response to unfolded protein GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0035966 response to topologically incorrect protein GO:0044057 regulation of system process GO:0060047 heart contraction GO:1903522 regulation of blood circulation |
Molecular Function |
GO:0008022 protein C-terminus binding GO:0031005 filamin binding |
Cellular Component |
GO:0015030 Cajal body GO:0015629 actin cytoskeleton GO:0016234 inclusion body GO:0016235 aggresome GO:0016604 nuclear body |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HSPB7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HSPB7 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HSPB7 in various data sets.
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Points in the above scatter plot represent the mutation difference of HSPB7 in various data sets.
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Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSPB7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSPB7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSPB7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSPB7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HSPB7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HSPB7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HSPB7 |
Name | heat shock 27kDa protein family, member 7 (cardiovascular) |
Aliases | cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HSPB7 collected from DrugBank database. |
There is no record. |