Browse HSPD1

Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion matrix.
Domain PF00118 TCP-1/cpn60 chaperonin family
Function

Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0001819 positive regulation of cytokine production
GO:0002200 somatic diversification of immune receptors
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0002208 somatic diversification of immunoglobulins involved in immune response
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002236 detection of misfolded protein
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002347 response to tumor cell
GO:0002366 leukocyte activation involved in immune response
GO:0002367 cytokine production involved in immune response
GO:0002368 B cell cytokine production
GO:0002377 immunoglobulin production
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002418 immune response to tumor cell
GO:0002424 T cell mediated immune response to tumor cell
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002456 T cell mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002705 positive regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002708 positive regulation of lymphocyte mediated immunity
GO:0002709 regulation of T cell mediated immunity
GO:0002711 positive regulation of T cell mediated immunity
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002819 regulation of adaptive immune response
GO:0002821 positive regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002831 regulation of response to biotic stimulus
GO:0002833 positive regulation of response to biotic stimulus
GO:0002834 regulation of response to tumor cell
GO:0002836 positive regulation of response to tumor cell
GO:0002837 regulation of immune response to tumor cell
GO:0002839 positive regulation of immune response to tumor cell
GO:0002840 regulation of T cell mediated immune response to tumor cell
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0002931 response to ischemia
GO:0006310 DNA recombination
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006979 response to oxidative stress
GO:0006986 response to unfolded protein
GO:0007159 leukocyte cell-cell adhesion
GO:0008637 apoptotic mitochondrial changes
GO:0009266 response to temperature stimulus
GO:0009306 protein secretion
GO:0009408 response to heat
GO:0009409 response to cold
GO:0010035 response to inorganic substance
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0014074 response to purine-containing compound
GO:0014823 response to activity
GO:0016064 immunoglobulin mediated immune response
GO:0016444 somatic cell DNA recombination
GO:0016445 somatic diversification of immunoglobulins
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019724 B cell mediated immunity
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0031349 positive regulation of defense response
GO:0031647 regulation of protein stability
GO:0031960 response to corticosteroid
GO:0032103 positive regulation of response to external stimulus
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032606 type I interferon production
GO:0032607 interferon-alpha production
GO:0032609 interferon-gamma production
GO:0032613 interleukin-10 production
GO:0032615 interleukin-12 production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0032647 regulation of interferon-alpha production
GO:0032649 regulation of interferon-gamma production
GO:0032653 regulation of interleukin-10 production
GO:0032655 regulation of interleukin-12 production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032727 positive regulation of interferon-alpha production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032943 mononuclear cell proliferation
GO:0033198 response to ATP
GO:0035966 response to topologically incorrect protein
GO:0036293 response to decreased oxygen levels
GO:0042026 protein refolding
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042116 macrophage activation
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043030 regulation of macrophage activation
GO:0043032 positive regulation of macrophage activation
GO:0043279 response to alkaloid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043627 response to estrogen
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045190 isotype switching
GO:0045785 positive regulation of cell adhesion
GO:0045862 positive regulation of proteolysis
GO:0046651 lymphocyte proliferation
GO:0046683 response to organophosphorus
GO:0048291 isotype switching to IgG isotypes
GO:0048545 response to steroid hormone
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050821 protein stabilization
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0051047 positive regulation of secretion
GO:0051084 'de novo' posttranslational protein folding
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051131 chaperone-mediated protein complex assembly
GO:0051222 positive regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051604 protein maturation
GO:0051788 response to misfolded protein
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0061077 chaperone-mediated protein folding
GO:0070482 response to oxygen levels
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070997 neuron death
GO:0071593 lymphocyte aggregation
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071839 apoptotic process in bone marrow
GO:0071865 regulation of apoptotic process in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow
GO:0072593 reactive oxygen species metabolic process
GO:0072604 interleukin-6 secretion
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903532 positive regulation of secretion by cell
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1904467 regulation of tumor necrosis factor secretion
GO:1904469 positive regulation of tumor necrosis factor secretion
GO:1904951 positive regulation of establishment of protein localization
GO:1990774 tumor necrosis factor secretion
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000778 positive regulation of interleukin-6 secretion
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function GO:0001530 lipopolysaccharide binding
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003725 double-stranded RNA binding
GO:0016887 ATPase activity
GO:0017046 peptide hormone binding
GO:0031625 ubiquitin protein ligase binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0042562 hormone binding
GO:0043559 insulin binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046982 protein heterodimerization activity
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051787 misfolded protein binding
Cellular Component GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005791 rough endoplasmic reticulum
GO:0005905 clathrin-coated pit
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0030061 mitochondrial crista
GO:0030135 coated vesicle
GO:0030141 secretory granule
GO:0031907 microbody lumen
GO:0032806 carboxy-terminal domain protein kinase complex
GO:0042579 microbody
GO:0042588 zymogen granule
GO:0043209 myelin sheath
GO:0043235 receptor complex
GO:0044438 microbody part
GO:0044439 peroxisomal part
GO:0044455 mitochondrial membrane part
GO:0045121 membrane raft
GO:0046696 lipopolysaccharide receptor complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:0099503 secretory vesicle
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
> KEGG and Reactome Pathway
 
KEGG hsa03018 RNA degradation
Reactome R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-392499: Metabolism of proteins
R-HSA-1268020: Mitochondrial protein import
R-HSA-8869496: TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HSPD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between HSPD1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
22396543Hepatocellular CarcinomaPromote immunity (NK cell function)ELISA results showed that the production of HSP60, HSP70, and HSP90 was up-regulated in both cell lines in a stress-specific manner. Acting as a decoy, the HSP-bearing exosomes efficiently stimulated NK cell cytotoxicity and granzyme B production, up-regulated the expression of inhibitory receptor CD94, and down-regulated the expression of activating receptors CD69, NKG2D, and NKp44.
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HSPD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HSPD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0710.801
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1160.973
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2150.935
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0190.954
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3310.883
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4630.874
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0480.934
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2210.931
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3950.886
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3330.891
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1790.962
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0650.473
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HSPD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSPD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSPD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSPD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSPD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HSPD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HSPD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHSPD1
Nameheat shock 60kDa protein 1 (chaperonin)
Aliases GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location2q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HSPD1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HSPD1.
ID Name Drug Type Targets #Targets
DB09130CopperSmall MoleculeA1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......141