Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. |
Biological Process |
GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007210 serotonin receptor signaling pathway GO:0008015 blood circulation GO:0009636 response to toxic substance GO:0014821 phasic smooth muscle contraction GO:0014827 intestine smooth muscle contraction GO:0014831 gastro-intestinal system smooth muscle contraction GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0035150 regulation of tube size GO:0042310 vasoconstriction GO:0042493 response to drug GO:0050795 regulation of behavior GO:0050880 regulation of blood vessel size GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0090066 regulation of anatomical structure size GO:0097553 calcium ion transmembrane import into cytosol GO:1902656 calcium ion import into cytosol GO:2000021 regulation of ion homeostasis |
Molecular Function |
GO:0004993 G-protein coupled serotonin receptor activity GO:0008227 G-protein coupled amine receptor activity GO:0030594 neurotransmitter receptor activity GO:0043176 amine binding GO:0051378 serotonin binding GO:0099589 serotonin receptor activity |
Cellular Component |
GO:0030425 dendrite |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04726 Serotonergic synapse hsa04742 Taste transduction |
Reactome |
R-HSA-375280: Amine ligand-binding receptors R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-390666: Serotonin receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HTR1D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HTR1D in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HTR1D in various data sets.
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Points in the above scatter plot represent the mutation difference of HTR1D in various data sets.
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Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HTR1D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HTR1D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HTR1D. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HTR1D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HTR1D expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HTR1D and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HTR1D |
Name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Aliases | RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ...... |
Chromosomal Location | 1p36.3-p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HTR1D collected from DrugBank database. |
Details on drugs targeting HTR1D.
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