Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
Biological Process |
GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0007210 serotonin receptor signaling pathway GO:0007623 circadian rhythm GO:0008015 blood circulation GO:0035150 regulation of tube size GO:0042310 vasoconstriction GO:0048511 rhythmic process GO:0050880 regulation of blood vessel size GO:0090066 regulation of anatomical structure size |
Molecular Function |
GO:0004993 G-protein coupled serotonin receptor activity GO:0008227 G-protein coupled amine receptor activity GO:0030594 neurotransmitter receptor activity GO:0099589 serotonin receptor activity |
Cellular Component |
GO:0030425 dendrite |
KEGG |
hsa04014 Ras signaling pathway hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04726 Serotonergic synapse |
Reactome |
R-HSA-375280: Amine ligand-binding receptors R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-390666: Serotonin receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HTR7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HTR7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HTR7 in various data sets.
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Points in the above scatter plot represent the mutation difference of HTR7 in various data sets.
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Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HTR7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HTR7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HTR7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HTR7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HTR7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HTR7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HTR7 |
Name | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Aliases | 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ...... |
Chromosomal Location | 10q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HTR7 collected from DrugBank database. |
Details on drugs targeting HTR7.
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