Browse HTR7

Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

> Gene Ontology
 
Biological Process GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007623 circadian rhythm
GO:0008015 blood circulation
GO:0035150 regulation of tube size
GO:0042310 vasoconstriction
GO:0048511 rhythmic process
GO:0050880 regulation of blood vessel size
GO:0090066 regulation of anatomical structure size
Molecular Function GO:0004993 G-protein coupled serotonin receptor activity
GO:0008227 G-protein coupled amine receptor activity
GO:0030594 neurotransmitter receptor activity
GO:0099589 serotonin receptor activity
Cellular Component GO:0030425 dendrite
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04726 Serotonergic synapse
Reactome R-HSA-375280: Amine ligand-binding receptors
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-390666: Serotonin receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HTR7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HTR7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HTR7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5880.119
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8650.167
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3790.486
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.270.586
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2050.851
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3450.77
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5430.329
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.2230.149
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3220.711
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1850.688
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.580.354
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.9190.00107
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HTR7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HTR7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HTR7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HTR7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HTR7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HTR7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HTR7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHTR7
Name5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location10q21-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HTR7 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HTR7.
ID Name Drug Type Targets #Targets
DB00216EletriptanSmall MoleculeHTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2B, HTR77
DB00246ZiprasidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB00247MethysergideSmall MoleculeHTR1A, HTR1B, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR78
DB00248CabergolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1 ......22
DB00321AmitriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......35
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00363ClozapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, ......27
DB00370MirtazapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......23
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00434CyproheptadineSmall MoleculeCHRM1, CHRM2, CHRM3, HRH1, HTR2A, HTR2C, HTR77
DB00458ImipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......25
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00589LisurideSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......15
DB00734RisperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HR ......15
DB00751EpinastineSmall MoleculeADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR76
DB00934MaprotilineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......17
DB00988DopamineSmall MoleculeDBH, DRD1, DRD1, DRD2, DRD3, DRD4, DRD5, DRD5, HTR1A, HTR3A, HTR3B ......17
DB01049Ergoloid mesylateSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, GABRA1 ......41
DB01200BromocriptineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......18
DB01224QuetiapineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......26
DB01238AripiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB01267PaliperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CYP2D6, CYP3A4, CYP3A5, DR ......18
DB04946IloperidoneSmall MoleculeADRA1A, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR2A, HTR6, ......11
DB06148MianserinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......23
DB06216AsenapineSmall MoleculeADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DR ......20
DB06288AmisulprideSmall MoleculeDRD2, DRD3, HTR2A, HTR74
DB08815LurasidoneSmall MoleculeADRA2A, ADRA2C, DRD2, HTR1A, HTR2A, HTR76
DB09068VortioxetineSmall MoleculeADRB1, HTR1A, HTR1B, HTR3A, HTR7, SLC6A46
DB09225ZotepineSmall MoleculeDRD1, DRD2, DRD5, HTR2A, HTR6, HTR7, SLC6A2, SLC6A48
DB09304SetiptilineSmall MoleculeADRA2A, ADRA2B, ADRA2C, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, ......19
DB13025TiaprideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HRH1, ......25
DB13988SB-269970Small MoleculeHTR71