Summary | |
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Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Note=Secretion increased during decidualization of endometrial stromal cells. |
Domain |
PF00219 Insulin-like growth factor binding protein PF07648 Kazal-type serine protease inhibitor domain PF13180 PDZ domain |
Function |
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). |
Biological Process |
GO:0001558 regulation of cell growth GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0016049 cell growth GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030514 negative regulation of BMP signaling pathway GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005520 insulin-like growth factor binding GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity GO:0019838 growth factor binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HTRA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HTRA3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HTRA3 in various data sets.
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Points in the above scatter plot represent the mutation difference of HTRA3 in various data sets.
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Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HTRA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HTRA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HTRA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HTRA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HTRA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HTRA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HTRA3 |
Name | HtrA serine peptidase 3 |
Aliases | Prsp; pregnancy-related serine protease; high-temperature requirement factor A3; probable serine protease HT ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HTRA3 collected from DrugBank database. |
There is no record. |