Browse HYDIN

Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell projection, cilium
Domain PF15780 Abnormal spindle-like microcephaly-assoc'd
PF17213 Hydin Adenylate kinase-like domain
Function

Required for ciliary motility.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0002064 epithelial cell development
GO:0003341 cilium movement
GO:0007018 microtubule-based movement
GO:0010927 cellular component assembly involved in morphogenesis
GO:0021591 ventricular system development
GO:0030031 cell projection assembly
GO:0035082 axoneme assembly
GO:0042384 cilium assembly
GO:0044782 cilium organization
GO:0060271 cilium morphogenesis
GO:0060438 trachea development
GO:0060541 respiratory system development
GO:1904158 axonemal central apparatus assembly
Molecular Function -
Cellular Component GO:0005929 cilium
GO:0005930 axoneme
GO:0044441 ciliary part
GO:0044447 axoneme part
GO:0097014 ciliary plasm
GO:1990716 axonemal central apparatus
GO:1990718 axonemal central pair projection
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HYDIN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HYDIN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HYDIN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2980.338
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3080.889
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2890.915
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1490.777
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5820.456
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3340.686
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2350.761
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2610.801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1640.495
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HYDIN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.35.98.40.576
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1032033.3-13.31
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277348.123.324.80.0258
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275948.127.1210.0844
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211757.129.427.70.111
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131169.245.523.70.408
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382726.322.24.10.777
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221327.323.14.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16142521.43.61
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HYDIN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HYDIN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HYDIN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HYDIN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HYDIN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HYDIN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHYDIN
NameHYDIN, axonemal central pair apparatus protein
Aliases DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ......
Chromosomal Location16q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HYDIN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.