Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell projection, cilium |
Domain |
PF15780 Abnormal spindle-like microcephaly-assoc'd PF17213 Hydin Adenylate kinase-like domain |
Function |
Required for ciliary motility. |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0002064 epithelial cell development GO:0003341 cilium movement GO:0007018 microtubule-based movement GO:0010927 cellular component assembly involved in morphogenesis GO:0021591 ventricular system development GO:0030031 cell projection assembly GO:0035082 axoneme assembly GO:0042384 cilium assembly GO:0044782 cilium organization GO:0060271 cilium morphogenesis GO:0060438 trachea development GO:0060541 respiratory system development GO:1904158 axonemal central apparatus assembly |
Molecular Function | - |
Cellular Component |
GO:0005929 cilium GO:0005930 axoneme GO:0044441 ciliary part GO:0044447 axoneme part GO:0097014 ciliary plasm GO:1990716 axonemal central apparatus GO:1990718 axonemal central pair projection |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HYDIN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HYDIN in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HYDIN in various data sets.
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Points in the above scatter plot represent the mutation difference of HYDIN in various data sets.
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Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HYDIN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HYDIN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HYDIN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HYDIN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HYDIN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HYDIN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HYDIN |
Name | HYDIN, axonemal central pair apparatus protein |
Aliases | DKFZp434D0513; KIAA1864; PPP1R31; CILD5; protein phosphatase 1, regulatory subunit 31; hydrocephalus inducin ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HYDIN collected from DrugBank database. |
There is no record. |