Browse HYKK

Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF01636 Phosphotransferase enzyme family
Function

Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

> Gene Ontology
 
Biological Process GO:0006520 cellular amino acid metabolic process
GO:0006553 lysine metabolic process
GO:0006554 lysine catabolic process
GO:0009063 cellular amino acid catabolic process
GO:0009066 aspartate family amino acid metabolic process
GO:0009068 aspartate family amino acid catabolic process
GO:0016054 organic acid catabolic process
GO:0044282 small molecule catabolic process
GO:0046395 carboxylic acid catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1901605 alpha-amino acid metabolic process
GO:1901606 alpha-amino acid catabolic process
Molecular Function GO:0047992 hydroxylysine kinase activity
Cellular Component GO:0005759 mitochondrial matrix
> KEGG and Reactome Pathway
 
KEGG hsa00310 Lysine degradation
hsa01100 Metabolic pathways
Reactome R-HSA-6788656: Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
R-HSA-71064: Lysine catabolism
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HYKK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HYKK in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HYKK in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7460.0055
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.2040.142
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4140.502
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0840.816
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.310.755
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1950.855
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1210.691
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1450.803
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0880.889
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.6760.44
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3380.764
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0020.984
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HYKK in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HYKK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HYKK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HYKK.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HYKK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HYKK expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HYKK and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHYKK
Namehydroxylysine kinase
Aliases LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HYKK collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.