Summary | |
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Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF01636 Phosphotransferase enzyme family |
Function |
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine. |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006553 lysine metabolic process GO:0006554 lysine catabolic process GO:0009063 cellular amino acid catabolic process GO:0009066 aspartate family amino acid metabolic process GO:0009068 aspartate family amino acid catabolic process GO:0016054 organic acid catabolic process GO:0044282 small molecule catabolic process GO:0046395 carboxylic acid catabolic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process |
Molecular Function |
GO:0047992 hydroxylysine kinase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00310 Lysine degradation hsa01100 Metabolic pathways |
Reactome |
R-HSA-6788656: Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism R-HSA-71064: Lysine catabolism R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HYKK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HYKK in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HYKK in various data sets.
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Points in the above scatter plot represent the mutation difference of HYKK in various data sets.
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Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HYKK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HYKK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HYKK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HYKK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HYKK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HYKK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HYKK |
Name | hydroxylysine kinase |
Aliases | LOC123688; 5-hydroxylysine kinase; AGPHD1; aminoglycoside phosphotransferase domain containing 1; 5-hydroxy- ...... |
Chromosomal Location | 15q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HYKK collected from DrugBank database. |
There is no record. |