Browse HYOU1

Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum lumen.
Domain PF00012 Hsp70 protein
Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

> Gene Ontology
 
Biological Process GO:0001666 response to hypoxia
GO:0002931 response to ischemia
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0006986 response to unfolded protein
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0036483 neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0036498 IRE1-mediated unfolded protein response
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0048193 Golgi vesicle transport
GO:0051402 neuron apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070482 response to oxygen levels
GO:0070997 neuron death
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900037 regulation of cellular response to hypoxia
GO:1900038 negative regulation of cellular response to hypoxia
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1903297 regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903381 regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0051087 chaperone binding
Cellular Component GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
GO:0030139 endocytic vesicle
GO:0031983 vesicle lumen
GO:0034663 endoplasmic reticulum chaperone complex
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0071682 endocytic vesicle lumen
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-392499: Metabolism of proteins
R-HSA-3000484: Scavenging by Class F Receptors
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-5653656: Vesicle-mediated transport
R-HSA-381038: XBP1(S) activates chaperone genes
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HYOU1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between HYOU1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
16424054MelanomaPromote immunityChaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activity. In this study, we determine the ability of grp170 and its structural domains to (a) bind to and present melanoma-associated antigen gp100 to the immune system and (b) to bind to receptors on APCs. Therefore, these studies suggest that molecular chaperoning is involved in stress protein interactions with APCs, antigen binding, and in eliciting antitumor immunity, thus bridging this ancient function of stress proteins in prokaryotes to their ability to elicit immunity in higher organisms.
24218449MelanomaPromote immunityDirecting the clinically relevant, melanoma Ag gp100 to mouse-derived DCs by molecular adjuvant and chaperone Grp170 substantially facilitates Ag access to the ER. Grp170 also strengthens the interaction of internalized protein Ag with molecular components involved in ER-associated protein dislocation and/or degradation, which culminates in cytosolic translocation for proteasome-dependent degradation and processing.
16849461MelanomaPromote immunityThe continued secretion of grp170 dramatically reduced the tumorigenicity of B16 tumor cells in vivo, although the modification did not alter its transformation phenotype and cell growth rate. C57BL/6 mice that rejected grp170-secreting B16 tumor cells (B16-sgrp170) developed a strong CTL response recognizing melanocyte differentiation Ag TRP2 and were resistant to subsequent tumor challenge.
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HYOU1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HYOU1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1010.714
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2860.91
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0340.985
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2680.523
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2950.901
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2330.938
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1430.773
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0040.998
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3820.858
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2790.886
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6020.833
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0880.242
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HYOU1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HYOU1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HYOU1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HYOU1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HYOU1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HYOU1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HYOU1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHYOU1
Namehypoxia up-regulated 1
Aliases ORP150; HSP12A; Grp170; glucose-regulated protein 170; GRP-170; ORP-150; 150 kDa oxygen-regulated protein; 1 ......
Chromosomal Location11q23.1-q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HYOU1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.