Summary | |
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Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF05432 Bone sialoprotein II (BSP-II) |
Function |
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0030198 extracellular matrix organization GO:0030282 bone mineralization GO:0031214 biomineral tissue development GO:0043062 extracellular structure organization |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction |
Reactome |
R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-216083: Integrin cell surface interactions |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IBSP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IBSP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IBSP in various data sets.
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Points in the above scatter plot represent the mutation difference of IBSP in various data sets.
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Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IBSP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IBSP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IBSP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IBSP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IBSP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IBSP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IBSP |
Name | integrin-binding sialoprotein |
Aliases | BSP; SP-II; BSP-II; bone sialoprotein; bone sialoprotein II; BSP II; cell-binding sialoprotein; Bone sialopr ...... |
Chromosomal Location | 4q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IBSP collected from DrugBank database. |
There is no record. |