Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF03921 Intercellular adhesion molecule (ICAM) |
Function |
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. ; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. ; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. |
Biological Process |
GO:0001101 response to acid chemical GO:0001541 ovarian follicle development GO:0001666 response to hypoxia GO:0001678 cellular glucose homeostasis GO:0001885 endothelial cell development GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001975 response to amphetamine GO:0002064 epithelial cell development GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002366 leukocyte activation involved in immune response GO:0002437 inflammatory response to antigenic stimulus GO:0002438 acute inflammatory response to antigenic stimulus GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002457 T cell antigen processing and presentation GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002526 acute inflammatory response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002691 regulation of cellular extravasation GO:0002693 positive regulation of cellular extravasation GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0003158 endothelium development GO:0006809 nitric oxide biosynthetic process GO:0006816 calcium ion transport GO:0007015 actin filament organization GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007159 leukocyte cell-cell adhesion GO:0007548 sex differentiation GO:0007568 aging GO:0007569 cell aging GO:0007605 sensory perception of sound GO:0008015 blood circulation GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0008360 regulation of cell shape GO:0008406 gonad development GO:0008584 male gonad development GO:0008585 female gonad development GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009314 response to radiation GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010212 response to ionizing radiation GO:0010477 response to sulfur dioxide GO:0010959 regulation of metal ion transport GO:0014075 response to amine GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019058 viral life cycle GO:0019062 virion attachment to host cell GO:0019229 regulation of vasoconstriction GO:0019882 antigen processing and presentation GO:0022406 membrane docking GO:0022602 ovulation cycle process GO:0022604 regulation of cell morphogenesis GO:0022614 membrane to membrane docking GO:0030031 cell projection assembly GO:0030041 actin filament polymerization GO:0030198 extracellular matrix organization GO:0030260 entry into host cell GO:0030335 positive regulation of cell migration GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030838 positive regulation of actin filament polymerization GO:0031334 positive regulation of protein complex assembly GO:0031341 regulation of cell killing GO:0031529 ruffle organization GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0032271 regulation of protein polymerization GO:0032273 positive regulation of protein polymerization GO:0032496 response to lipopolysaccharide GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033500 carbohydrate homeostasis GO:0033627 cell adhesion mediated by integrin GO:0034284 response to monosaccharide GO:0034341 response to interferon-gamma GO:0034612 response to tumor necrosis factor GO:0034698 response to gonadotropin GO:0035150 regulation of tube size GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0042310 vasoconstriction GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042698 ovulation cycle GO:0043062 extracellular structure organization GO:0043200 response to amino acid GO:0043254 regulation of protein complex assembly GO:0043271 negative regulation of ion transport GO:0043279 response to alkaloid GO:0043410 positive regulation of MAPK cascade GO:0044057 regulation of system process GO:0044089 positive regulation of cellular component biogenesis GO:0044406 adhesion of symbiont to host GO:0044409 entry into host GO:0044650 adhesion of symbiont to host cell GO:0045123 cellular extravasation GO:0045137 development of primary sexual characteristics GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045446 endothelial cell differentiation GO:0045471 response to ethanol GO:0045907 positive regulation of vasoconstriction GO:0046209 nitric oxide metabolic process GO:0046545 development of primary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046660 female sex differentiation GO:0046661 male sex differentiation GO:0046688 response to copper ion GO:0046718 viral entry into host cell GO:0046813 receptor-mediated virion attachment to host cell GO:0048511 rhythmic process GO:0048608 reproductive structure development GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050880 regulation of blood vessel size GO:0050900 leukocyte migration GO:0050954 sensory perception of mechanical stimulus GO:0051051 negative regulation of transport GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051258 protein polymerization GO:0051272 positive regulation of cellular component movement GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0051924 regulation of calcium ion transport GO:0051926 negative regulation of calcium ion transport GO:0060008 Sertoli cell differentiation GO:0060009 Sertoli cell development GO:0060333 interferon-gamma-mediated signaling pathway GO:0060491 regulation of cell projection assembly GO:0061028 establishment of endothelial barrier GO:0061458 reproductive system development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070555 response to interleukin-1 GO:0070838 divalent metal ion transport GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071312 cellular response to alkaloid GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071346 cellular response to interferon-gamma GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071396 cellular response to lipid GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0072511 divalent inorganic cation transport GO:0072577 endothelial cell apoptotic process GO:0072593 reactive oxygen species metabolic process GO:0090066 regulation of anatomical structure size GO:0097178 ruffle assembly GO:0097191 extrinsic apoptotic signaling pathway GO:0097305 response to alcohol GO:0097368 establishment of Sertoli cell barrier GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1900027 regulation of ruffle assembly GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:1904407 positive regulation of nitric oxide metabolic process GO:1990267 response to transition metal nanoparticle GO:2000147 positive regulation of cell motility GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001618 virus receptor activity GO:0005178 integrin binding GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0001772 immunological synapse GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0009897 external side of plasma membrane GO:0030055 cell-substrate junction GO:0045121 membrane raft GO:0098552 side of membrane GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04064 NF-kappa B signaling pathway hsa04514 Cell adhesion molecules (CAMs) hsa04650 Natural killer cell mediated cytotoxicity hsa04668 TNF signaling pathway hsa04670 Leukocyte transendothelial migration |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1474244: Extracellular matrix organization R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083: Integrin cell surface interactions R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ICAM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ICAM1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ICAM1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ICAM1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ICAM1 in various data sets.
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Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ICAM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ICAM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ICAM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ICAM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ICAM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ICAM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ICAM1 |
Name | intercellular adhesion molecule 1 |
Aliases | CD54; human rhinovirus receptor; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion mole ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ICAM1 collected from DrugBank database. |
Details on drugs targeting ICAM1.
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