Summary | |
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Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus. |
Domain |
PF00010 Helix-loop-helix DNA-binding domain |
Function |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). |
Biological Process |
GO:0001503 ossification GO:0001525 angiogenesis GO:0001649 osteoblast differentiation GO:0001667 ameboidal-type cell migration GO:0001885 endothelial cell development GO:0001886 endothelial cell morphogenesis GO:0002064 epithelial cell development GO:0003158 endothelium development GO:0003382 epithelial cell morphogenesis GO:0007015 actin filament organization GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007507 heart development GO:0007623 circadian rhythm GO:0010621 negative regulation of transcription by transcription factor localization GO:0010631 epithelial cell migration GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016358 dendrite development GO:0022604 regulation of cell morphogenesis GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030509 BMP signaling pathway GO:0030856 regulation of epithelial cell differentiation GO:0030857 negative regulation of epithelial cell differentiation GO:0031345 negative regulation of cell projection organization GO:0031589 cell-substrate adhesion GO:0031647 regulation of protein stability GO:0031648 protein destabilization GO:0032091 negative regulation of protein binding GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032963 collagen metabolic process GO:0032970 regulation of actin filament-based process GO:0036164 cell-abiotic substrate adhesion GO:0043392 negative regulation of DNA binding GO:0043393 regulation of protein binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043496 regulation of protein homodimerization activity GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044089 positive regulation of cellular component biogenesis GO:0044236 multicellular organism metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045446 endothelial cell differentiation GO:0045601 regulation of endothelial cell differentiation GO:0045602 negative regulation of endothelial cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045765 regulation of angiogenesis GO:0046677 response to antibiotic GO:0048511 rhythmic process GO:0048514 blood vessel morphogenesis GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050768 negative regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050774 negative regulation of dendrite morphogenesis GO:0051017 actin filament bundle assembly GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051961 negative regulation of nervous system development GO:0060425 lung morphogenesis GO:0060426 lung vasculature development GO:0060541 respiratory system development GO:0061572 actin filament bundle organization GO:0070849 response to epidermal growth factor GO:0071364 cellular response to epidermal growth factor stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0071867 response to monoamine GO:0071868 cellular response to monoamine stimulus GO:0071869 response to catecholamine GO:0071870 cellular response to catecholamine stimulus GO:0090074 negative regulation of protein homodimerization activity GO:0090130 tissue migration GO:0090132 epithelium migration GO:1901342 regulation of vasculature development GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903350 response to dopamine GO:1903351 cellular response to dopamine GO:1990089 response to nerve growth factor GO:1990090 cellular response to nerve growth factor stimulus GO:2000171 negative regulation of dendrite development GO:2000677 regulation of transcription regulatory region DNA binding GO:2000678 negative regulation of transcription regulatory region DNA binding |
Molecular Function |
GO:0008022 protein C-terminus binding GO:0008134 transcription factor binding GO:0043621 protein self-association GO:0047485 protein N-terminus binding GO:0070628 proteasome binding |
Cellular Component |
GO:0005813 centrosome |
KEGG |
hsa04015 Rap1 signaling pathway hsa04350 TGF-beta signaling pathway hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-2559585: Oncogene Induced Senescence |
Summary | |
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Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ID1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ID1 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ID1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ID1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ID1 in various data sets.
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Summary | |
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Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ID1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ID1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ID1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ID1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ID1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ID1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ID1 |
Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Aliases | dJ857M17.1.2; bHLHb24; DNA-binding protein inhibitor ID-1; ID; class B basic helix-loop-helix protein 24; dJ ...... |
Chromosomal Location | 20q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ID1 collected from DrugBank database. |
There is no record. |