Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00010 Helix-loop-helix DNA-binding domain |
Function |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. |
Biological Process |
GO:0001101 response to acid chemical GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001822 kidney development GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0007507 heart development GO:0007517 muscle organ development GO:0007623 circadian rhythm GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030903 notochord development GO:0042476 odontogenesis GO:0042692 muscle cell differentiation GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0048511 rhythmic process GO:0048568 embryonic organ development GO:0051052 regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0070542 response to fatty acid GO:0071229 cellular response to acid chemical GO:0071396 cellular response to lipid GO:0071398 cellular response to fatty acid GO:0071407 cellular response to organic cyclic compound GO:0072001 renal system development GO:0072750 cellular response to leptomycin B GO:1901344 response to leptomycin B |
Molecular Function |
GO:0003714 transcription corepressor activity GO:0008134 transcription factor binding GO:0043177 organic acid binding GO:1901707 leptomycin B binding |
Cellular Component | - |
KEGG |
hsa04350 TGF-beta signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome | - |
Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ID3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ID3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ID3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ID3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ID3 in various data sets.
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Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ID3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ID3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ID3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ID3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ID3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ID3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ID3 |
Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
Aliases | HEIR-1; bHLHb25; ID-like protein inhibitor HLH 1R21; class B basic helix-loop-helix protein 25; helix-loop-h ...... |
Chromosomal Location | 1p36.13-p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ID3 collected from DrugBank database. |
There is no record. |