Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Mitochondrion. |
Domain |
PF13176 Tetratricopeptide repeat PF13181 Tetratricopeptide repeat |
Function |
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. |
Biological Process |
GO:0009615 response to virus GO:0034340 response to type I interferon GO:0035455 response to interferon-alpha GO:0035457 cellular response to interferon-alpha GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0071357 cellular response to type I interferon GO:0098542 defense response to other organism |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling |
Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IFIT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IFIT3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IFIT3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IFIT3 in various data sets.
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There is no record. |
Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IFIT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IFIT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IFIT3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IFIT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IFIT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IFIT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IFIT3 |
Name | interferon-induced protein with tetratricopeptide repeats 3 |
Aliases | ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IFIT3 collected from DrugBank database. |
There is no record. |