Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 3: Secreted |
Domain |
PF09294 Interferon-alpha/beta receptor PF01108 Tissue factor |
Function |
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). |
Biological Process |
GO:0001959 regulation of cytokine-mediated signaling pathway GO:0007259 JAK-STAT cascade GO:0009615 response to virus GO:0034340 response to type I interferon GO:0035455 response to interferon-alpha GO:0035456 response to interferon-beta GO:0045088 regulation of innate immune response GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0060759 regulation of response to cytokine stimulus GO:0071357 cellular response to type I interferon GO:0097696 STAT cascade GO:0098542 defense response to other organism |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004904 interferon receptor activity GO:0004905 type I interferon receptor activity GO:0019955 cytokine binding GO:0042015 interleukin-20 binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04380 Osteoclast differentiation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04630 Jak-STAT signaling pathway hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-912694: Regulation of IFNA signaling |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IFNAR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IFNAR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IFNAR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of IFNAR2 in various data sets.
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Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IFNAR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IFNAR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IFNAR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IFNAR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IFNAR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IFNAR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IFNAR2 |
Name | interferon (alpha, beta and omega) receptor 2 |
Aliases | IFNABR; IFN-R; IFNARB; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon ...... |
Chromosomal Location | 21q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IFNAR2 collected from DrugBank database. |
Details on drugs targeting IFNAR2.
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