Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF07140 Interferon gamma receptor (IFNGR1) PF01108 Tissue factor |
Function |
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). |
Biological Process |
GO:0001959 regulation of cytokine-mediated signaling pathway GO:0009615 response to virus GO:0034341 response to interferon-gamma GO:0045088 regulation of innate immune response GO:0060330 regulation of response to interferon-gamma GO:0060333 interferon-gamma-mediated signaling pathway GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0060759 regulation of response to cytokine stimulus GO:0071346 cellular response to interferon-gamma |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004904 interferon receptor activity GO:0004906 interferon-gamma receptor activity GO:0019955 cytokine binding GO:0042015 interleukin-20 binding |
Cellular Component |
GO:0014069 postsynaptic density GO:0030425 dendrite GO:0060076 excitatory synapse GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04380 Osteoclast differentiation hsa04630 Jak-STAT signaling pathway hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-877312: Regulation of IFNG signaling |
Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IFNGR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IFNGR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IFNGR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IFNGR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IFNGR1 in various data sets.
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Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IFNGR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IFNGR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IFNGR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IFNGR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IFNGR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IFNGR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IFNGR1 |
Name | interferon gamma receptor 1 |
Aliases | CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ...... |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IFNGR1 collected from DrugBank database. |
Details on drugs targeting IFNGR1.
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