Browse IGF2BP1

Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendrite Cell projection, dendritic spine Cell projection, growth cone. Cell projection, filopodium Cell projection, axon Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity). In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity). Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity). In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity). In axons, predominantly found in axonal branches and their growth cones (By similarity). In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity). Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by the NMDA receptor agonist (By similarity). In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies.
Domain PF00013 KH domain
PF00076 RNA recognition motif. (a.k.a. RRM
Function

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.

> Gene Ontology
 
Biological Process GO:0006403 RNA localization
GO:0006417 regulation of translation
GO:0010608 posttranscriptional regulation of gene expression
GO:0010610 regulation of mRNA stability involved in response to stress
GO:0015931 nucleobase-containing compound transport
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021846 cell proliferation in forebrain
GO:0022013 pallium cell proliferation in forebrain
GO:0030900 forebrain development
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0042035 regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042107 cytokine metabolic process
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0043489 RNA stabilization
GO:0048255 mRNA stabilization
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0051028 mRNA transport
GO:0051236 establishment of RNA localization
GO:0061351 neural precursor cell proliferation
GO:0070934 CRD-mediated mRNA stabilization
GO:0097150 neuronal stem cell population maintenance
GO:0098727 maintenance of cell number
Molecular Function GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Cellular Component GO:0010494 cytoplasmic stress granule
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0031252 cell leading edge
GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043197 dendritic spine
GO:0044309 neuron spine
GO:0070937 CRD-mediated mRNA stability complex
GO:0098794 postsynapse
GO:0098858 actin-based cell projection
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-428359: Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-162582: Signal Transduction
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IGF2BP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IGF2BP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IGF2BP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.890.0887
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.7170.0384
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3020.677
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0290.967
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1980.869
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3220.827
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.490.664
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.070.488
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11122.6540.11
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1290.877
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1460.895
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.960.0295
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IGF2BP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.12.78.40.12
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.317.6-3.31
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.418.2-2.81
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGF2BP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGF2BP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGF2BP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGF2BP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IGF2BP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IGF2BP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIGF2BP1
Nameinsulin-like growth factor 2 mRNA binding protein 1
Aliases IGF II mRNA binding protein 1; CRD-BP; CRDBP; VICKZ1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding prote ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IGF2BP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.