Browse IGFBP1

Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00219 Insulin-like growth factor binding protein
PF00086 Thyroglobulin type-1 repeat
Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030307 positive regulation of cell growth
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031099 regeneration
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036499 PERK-mediated unfolded protein response
GO:0042246 tissue regeneration
GO:0043434 response to peptide hormone
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0045927 positive regulation of growth
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0060070 canonical Wnt signaling pathway
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
Molecular Function GO:0005520 insulin-like growth factor binding
GO:0019838 growth factor binding
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-380994: ATF4 activates genes
R-HSA-392499: Metabolism of proteins
R-HSA-381042: PERK regulates gene expression
R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-381119: Unfolded Protein Response (UPR)
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IGFBP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IGFBP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
16222695Gestational Trophoblastic TumorPromote immunityQuantitative RNA analysis confirmed down-regulation of ferritin light polypeptide (FTL) (P = 0.037) and insulin-like growth factor binding protein 1 (IGFBP1) (P = 0.037) in HM that subsequently developed GTN when compared with those HM that regressed. Immunohistochemical analysis further confirmed reduced IGFBP1 protein (P = 0.03) expression in HM that developed GTN. Findings showed that reduced expression of genes related to cell invasion and immunosuppression, especially FTL and IGFBP1, were associated with development of GTN, and this finding may provide a better understanding of the pathogenesis of GTN.
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IGFBP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IGFBP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2910.707
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.150.35
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.350.197
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9340.351
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.0190.193
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4310.823
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1990.826
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1540.935
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0740.966
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.7020.323
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.1590.599
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1290.655
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IGFBP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGFBP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGFBP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGFBP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGFBP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IGFBP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IGFBP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIGFBP1
Nameinsulin-like growth factor binding protein 1
Aliases IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ......
Chromosomal Location7p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IGFBP1 collected from DrugBank database.
> Drugs from DrugBank database
 

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