Summary | |
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Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00219 Insulin-like growth factor binding protein PF00086 Thyroglobulin type-1 repeat |
Function |
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. |
Biological Process |
GO:0001558 regulation of cell growth GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0007568 aging GO:0008286 insulin receptor signaling pathway GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030307 positive regulation of cell growth GO:0030968 endoplasmic reticulum unfolded protein response GO:0031099 regeneration GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036499 PERK-mediated unfolded protein response GO:0042246 tissue regeneration GO:0043434 response to peptide hormone GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO:0045927 positive regulation of growth GO:0048009 insulin-like growth factor receptor signaling pathway GO:0060070 canonical Wnt signaling pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:1901652 response to peptide GO:1901653 cellular response to peptide |
Molecular Function |
GO:0005520 insulin-like growth factor binding GO:0019838 growth factor binding GO:0031994 insulin-like growth factor I binding GO:0031995 insulin-like growth factor II binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-380994: ATF4 activates genes R-HSA-392499: Metabolism of proteins R-HSA-381042: PERK regulates gene expression R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381119: Unfolded Protein Response (UPR) |
Summary | |
---|---|
Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IGFBP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IGFBP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IGFBP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IGFBP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IGFBP1 in various data sets.
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Summary | |
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Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGFBP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGFBP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGFBP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGFBP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IGFBP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IGFBP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IGFBP1 |
Name | insulin-like growth factor binding protein 1 |
Aliases | IGF-BP25; AFBP; hIGFBP-1; PP12; placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associ ...... |
Chromosomal Location | 7p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IGFBP1 collected from DrugBank database. |
There is no record. |