TISIDB

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted.
Domain	PF00219 Insulin-like growth factor binding protein PF00086 Thyroglobulin type-1 repeat
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001558 regulation of cell growth GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010906 regulation of glucose metabolic process GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0019318 hexose metabolic process GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0043410 positive regulation of MAPK cascade GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway GO:0044262 cellular carbohydrate metabolic process GO:0044342 type B pancreatic cell proliferation GO:0044723 single-organism carbohydrate metabolic process GO:0048009 insulin-like growth factor receptor signaling pathway GO:0050673 epithelial cell proliferation GO:0060070 canonical Wnt signaling pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt
Molecular Function	GO:0005520 insulin-like growth factor binding GO:0019838 growth factor binding GO:0031994 insulin-like growth factor I binding GO:0031995 insulin-like growth factor II binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-392499: Metabolism of proteins R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between IGFBP4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of IGFBP4 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of IGFBP4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.337	0.371
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.814	0.81
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.025	0.991
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.328	0.484
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.22	0.937
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.47	0.889
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.114	0.847
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.378	0.846
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.295	0.898
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.922	0.73
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.181	0.777
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.529	6.27e-05

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of IGFBP4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	0	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	0	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGFBP4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGFBP4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGFBP4. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGFBP4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of IGFBP4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between IGFBP4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	IGFBP4
Name	insulin-like growth factor binding protein 4
Aliases	IBP4; BP-4; HT29-IGFBP; IGFBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4; IBP-4
Chromosomal Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting IGFBP4 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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