Summary | |
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Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00219 Insulin-like growth factor binding protein PF00086 Thyroglobulin type-1 repeat |
Function |
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
Biological Process |
GO:0001503 ossification GO:0001558 regulation of cell growth GO:0001649 osteoblast differentiation GO:0001942 hair follicle development GO:0003012 muscle system process GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006417 regulation of translation GO:0007565 female pregnancy GO:0007568 aging GO:0008544 epidermis development GO:0010608 posttranscriptional regulation of gene expression GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010906 regulation of glucose metabolic process GO:0014074 response to purine-containing compound GO:0014733 regulation of skeletal muscle adaptation GO:0014734 skeletal muscle hypertrophy GO:0014741 negative regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014745 negative regulation of muscle adaptation GO:0014812 muscle cell migration GO:0014888 striated muscle adaptation GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014912 negative regulation of smooth muscle cell migration GO:0016049 cell growth GO:0017148 negative regulation of translation GO:0019318 hexose metabolic process GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022612 gland morphogenesis GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030336 negative regulation of cell migration GO:0030879 mammary gland development GO:0031069 hair follicle morphogenesis GO:0033002 muscle cell proliferation GO:0033500 carbohydrate homeostasis GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0040013 negative regulation of locomotion GO:0042303 molting cycle GO:0042593 glucose homeostasis GO:0042633 hair cycle GO:0042692 muscle cell differentiation GO:0043434 response to peptide hormone GO:0043491 protein kinase B signaling GO:0043500 muscle adaptation GO:0043501 skeletal muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043588 skin development GO:0044057 regulation of system process GO:0044262 cellular carbohydrate metabolic process GO:0044342 type B pancreatic cell proliferation GO:0044706 multi-multicellular organism process GO:0044723 single-organism carbohydrate metabolic process GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045926 negative regulation of growth GO:0046683 response to organophosphorus GO:0048009 insulin-like growth factor receptor signaling pathway GO:0048286 lung alveolus development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0048730 epidermis morphogenesis GO:0048732 gland development GO:0048771 tissue remodeling GO:0050673 epithelial cell proliferation GO:0051146 striated muscle cell differentiation GO:0051271 negative regulation of cellular component movement GO:0051591 response to cAMP GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0060056 mammary gland involution GO:0060416 response to growth hormone GO:0060443 mammary gland morphogenesis GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0071320 cellular response to cAMP GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0090257 regulation of muscle system process GO:0098773 skin epidermis development GO:1901652 response to peptide GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1904204 regulation of skeletal muscle hypertrophy GO:1904205 negative regulation of skeletal muscle hypertrophy GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0001968 fibronectin binding GO:0005520 insulin-like growth factor binding GO:0019838 growth factor binding GO:0031994 insulin-like growth factor I binding GO:0031995 insulin-like growth factor II binding |
Cellular Component |
GO:0016942 insulin-like growth factor binding protein complex GO:0036454 growth factor complex GO:0042567 insulin-like growth factor ternary complex |
KEGG | - |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IGFBP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IGFBP5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IGFBP5 in various data sets.
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Points in the above scatter plot represent the mutation difference of IGFBP5 in various data sets.
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Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGFBP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGFBP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGFBP5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGFBP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IGFBP5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IGFBP5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IGFBP5 |
Name | insulin-like growth factor binding protein 5 |
Aliases | IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5 |
Chromosomal Location | 2q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IGFBP5 collected from DrugBank database. |
There is no record. |