Summary | |
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Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell junction, synapse Note=Enriched at the excitatory synapses in mature neurons. |
Domain |
PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain |
Function |
Functions in dendrite outgrowth and synapse maturation. |
Biological Process |
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0016358 dendrite development GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules |
Molecular Function |
GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion |
Cellular Component |
GO:0030424 axon GO:0030425 dendrite GO:0060077 inhibitory synapse |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IGSF9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IGSF9 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IGSF9 in various data sets.
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Points in the above scatter plot represent the mutation difference of IGSF9 in various data sets.
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Summary | |
---|---|
Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGSF9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGSF9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGSF9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGSF9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IGSF9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IGSF9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IGSF9 |
Name | immunoglobulin superfamily, member 9 |
Aliases | KIAA1355; Nrt1; IGSF9A; FP18798A; immunoglobulin superfamily member 9A; Protein turtle homolog A |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IGSF9 collected from DrugBank database. |
There is no record. |