Browse IKZF1

Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events. ; SUBCELLULAR LOCATION: Isoform Ik2: Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). ; SUBCELLULAR LOCATION: Isoform Ik6: Cytoplasm
Domain -
Function

Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

> Gene Ontology
 
Biological Process GO:0002262 myeloid cell homeostasis
GO:0002521 leukocyte differentiation
GO:0007498 mesoderm development
GO:0030098 lymphocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0034101 erythrocyte homeostasis
GO:0048872 homeostasis of number of cells
Molecular Function -
Cellular Component GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005720 nuclear heterochromatin
GO:0005721 pericentric heterochromatin
GO:0031618 nuclear pericentric heterochromatin
GO:0044454 nuclear chromosome part
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IKZF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IKZF1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24778448MelanomaInhibit immunity (T cell function)Naive murine CD8 T cells haplo-insufficient for Ikzf1 failed to upregulate Ikaros, produced autocrine IL-2, and differentiated in an IL-2-dependent manner into IFN-γ-producing CTLs in response to TCR/CD28 stimulation alone. Furthermore, Ikzf1 haplo-insufficient CD8(+) T cells were more effective at controlling Listeria infection and B16 melanoma growth in vivo, and they could provide help to neighboring, non-IL-2-producing cells to differentiate into IFN-γ-producing effectors.
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IKZF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IKZF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0330.944
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6180.582
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5080.563
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2530.595
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4180.656
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.110.372
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6590.207
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.0420.442
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2410.873
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.7170.0821
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5120.329
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2330.262
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IKZF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IKZF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IKZF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IKZF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IKZF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IKZF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IKZF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIKZF1
NameIKAROS family zinc finger 1 (Ikaros)
Aliases hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ......
Chromosomal Location7p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IKZF1 collected from DrugBank database.
> Drugs from DrugBank database
 

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