Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events. ; SUBCELLULAR LOCATION: Isoform Ik2: Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). ; SUBCELLULAR LOCATION: Isoform Ik6: Cytoplasm |
Domain | - |
Function |
Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). |
Biological Process |
GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0007498 mesoderm development GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030218 erythrocyte differentiation GO:0034101 erythrocyte homeostasis GO:0048872 homeostasis of number of cells |
Molecular Function | - |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0005720 nuclear heterochromatin GO:0005721 pericentric heterochromatin GO:0031618 nuclear pericentric heterochromatin GO:0044454 nuclear chromosome part GO:0098687 chromosomal region |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IKZF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IKZF1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IKZF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IKZF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IKZF1 in various data sets.
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Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IKZF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IKZF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IKZF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IKZF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IKZF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IKZF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IKZF1 |
Name | IKAROS family zinc finger 1 (Ikaros) |
Aliases | hIk-1; LyF-1; Hs.54452; IKAROS; PPP1R92; protein phosphatase 1, regulatory subunit 92; ZNFN1A1; zinc finger ...... |
Chromosomal Location | 7p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IKZF1 collected from DrugBank database. |
There is no record. |