Browse IKZF3

Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm.
Domain -
Function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

> Gene Ontology
 
Biological Process GO:0002521 leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0007498 mesoderm development
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030888 regulation of B cell proliferation
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0045577 regulation of B cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0046651 lymphocyte proliferation
GO:0050670 regulation of lymphocyte proliferation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0051249 regulation of lymphocyte activation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:1902105 regulation of leukocyte differentiation
GO:1903706 regulation of hemopoiesis
Molecular Function GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0046982 protein heterodimerization activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IKZF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IKZF3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IKZF3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0810.88
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7920.389
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4480.588
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2120.606
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2940.846
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8490.646
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.6050.0311
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.4430.0831
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8290.565
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0710.14
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5480.103
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0040.98
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IKZF3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.46.80.61
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IKZF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IKZF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IKZF3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IKZF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IKZF3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IKZF3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIKZF3
NameIKAROS family zinc finger 3 (Aiolos)
Aliases Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IKZF3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.