Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. |
Domain | - |
Function |
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
Biological Process |
GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0007498 mesoderm development GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030888 regulation of B cell proliferation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0045577 regulation of B cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0046651 lymphocyte proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0051249 regulation of lymphocyte activation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:1902105 regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis |
Molecular Function |
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IKZF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of IKZF3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IKZF3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of IKZF3 in various data sets.
|
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IKZF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IKZF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IKZF3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IKZF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IKZF3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IKZF3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IKZF3 |
Name | IKAROS family zinc finger 3 (Aiolos) |
Aliases | Aiolos; ZNFN1A3; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; zinc finger DNA binding protein Aiolos; ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IKZF3 collected from DrugBank database. |
There is no record. |