Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). |
Biological Process | - |
Molecular Function |
GO:0008134 transcription factor binding GO:0043425 bHLH transcription factor binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0005813 centrosome |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IKZF4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IKZF4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IKZF4 in various data sets.
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Points in the above scatter plot represent the mutation difference of IKZF4 in various data sets.
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Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IKZF4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IKZF4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IKZF4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IKZF4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IKZF4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IKZF4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IKZF4 |
Name | IKAROS family zinc finger 4 (Eos) |
Aliases | ZNFN1A4; zinc finger protein, subfamily 1A, 4 (Eos); ikaros family zinc finger protein 4; zinc finger transc ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IKZF4 collected from DrugBank database. |
There is no record. |