Summary | |
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Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF07400 Interleukin 11 |
Function |
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. |
Biological Process |
GO:0002521 leukocyte differentiation GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0023061 signal release GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030183 B cell differentiation GO:0030219 megakaryocyte differentiation GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0042113 B cell activation GO:0043410 positive regulation of MAPK cascade GO:0045444 fat cell differentiation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:1903531 negative regulation of secretion by cell |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005142 interleukin-11 receptor binding GO:0008083 growth factor activity GO:0070851 growth factor receptor binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-6788467: IL-6-type cytokine receptor ligand interactions R-HSA-168256: Immune System R-HSA-6783589: Interleukin-6 family signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL11 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL11 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL11 in various data sets.
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Summary | |
---|---|
Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL11 |
Name | interleukin 11 |
Aliases | IL-11; AGIF; adipogenesis inhibitory factor; oprelvekin; Interleukin-11 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |