Summary | |
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Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF03039 Interleukin-12 alpha subunit |
Function |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
Biological Process |
GO:0001562 response to protozoan GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0001914 regulation of T cell mediated cytotoxicity GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002347 response to tumor cell GO:0002407 dendritic cell chemotaxis GO:0002418 immune response to tumor cell GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002423 natural killer cell mediated immune response to tumor cell GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002717 positive regulation of natural killer cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002834 regulation of response to tumor cell GO:0002836 positive regulation of response to tumor cell GO:0002837 regulation of immune response to tumor cell GO:0002839 positive regulation of immune response to tumor cell GO:0002855 regulation of natural killer cell mediated immune response to tumor cell GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0007050 cell cycle arrest GO:0007159 leukocyte cell-cell adhesion GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009615 response to virus GO:0010224 response to UV-B GO:0010657 muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0010661 positive regulation of muscle cell apoptotic process GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030101 natural killer cell activation GO:0030217 T cell differentiation GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0032609 interferon-gamma production GO:0032620 interleukin-17 production GO:0032649 regulation of interferon-gamma production GO:0032660 regulation of interleukin-17 production GO:0032700 negative regulation of interleukin-17 production GO:0032729 positive regulation of interferon-gamma production GO:0032814 regulation of natural killer cell activation GO:0032816 positive regulation of natural killer cell activation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033002 muscle cell proliferation GO:0034390 smooth muscle cell apoptotic process GO:0034391 regulation of smooth muscle cell apoptotic process GO:0034393 positive regulation of smooth muscle cell apoptotic process GO:0036336 dendritic cell migration GO:0040017 positive regulation of locomotion GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042504 tyrosine phosphorylation of Stat4 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042519 regulation of tyrosine phosphorylation of Stat4 protein GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042742 defense response to bacterium GO:0042832 defense response to protozoan GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0045786 negative regulation of cell cycle GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046631 alpha-beta T cell activation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046651 lymphocyte proliferation GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050830 defense response to Gram-positive bacterium GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051132 NK T cell activation GO:0051133 regulation of NK T cell activation GO:0051135 positive regulation of NK T cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0060326 cell chemotaxis GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0097191 extrinsic apoptotic signaling pathway GO:0097696 STAT cascade GO:0098542 defense response to other organism GO:0098586 cellular response to virus GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000147 positive regulation of cell motility GO:2000508 regulation of dendritic cell chemotaxis GO:2000510 positive regulation of dendritic cell chemotaxis |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005143 interleukin-12 receptor binding GO:0008083 growth factor activity GO:0019955 cytokine binding GO:0019972 interleukin-12 binding GO:0019975 interleukin-17 binding GO:0042163 interleukin-12 beta subunit binding GO:0045513 interleukin-27 binding GO:0046982 protein heterodimerization activity GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0043514 interleukin-12 complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04620 Toll-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-6788467: IL-6-type cytokine receptor ligand interactions R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-447115: Interleukin-12 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-6783589: Interleukin-6 family signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL12A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL12A and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL12A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL12A in various data sets.
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Points in the above scatter plot represent the mutation difference of IL12A in various data sets.
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Summary | |
---|---|
Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL12A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL12A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL12A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL12A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL12A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL12A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IL12A |
Name | interleukin 12A |
Aliases | IL-12A; NFSK; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation facto ...... |
Chromosomal Location | 3q25.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL12A collected from DrugBank database. |
There is no record. |