Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein Nucleus membrane Single-pass type I membrane protein Note=Mainly found associated with the nuclear membrane.; SUBCELLULAR LOCATION: Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space. |
Domain | - |
Function |
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. |
Biological Process | - |
Molecular Function |
GO:0004896 cytokine receptor activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0030659 cytoplasmic vesicle membrane GO:0031965 nuclear membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL15RA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL15RA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL15RA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL15RA in various data sets.
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Points in the above scatter plot represent the mutation difference of IL15RA in various data sets.
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Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL15RA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL15RA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL15RA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL15RA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL15RA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL15RA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL15RA |
Name | interleukin 15 receptor, alpha |
Aliases | CD215; IL-15RA; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interl ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL15RA collected from DrugBank database. |
There is no record. |