Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Interleukin-16: Secreted.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm ; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus. |
Domain |
PF00595 PDZ domain (Also known as DHR or GLGF) |
Function |
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
Biological Process |
GO:0030595 leukocyte chemotaxis GO:0032103 positive regulation of response to external stimulus GO:0040017 positive regulation of locomotion GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050927 positive regulation of positive chemotaxis GO:0050930 induction of positive chemotaxis GO:0060326 cell chemotaxis |
Molecular Function |
GO:0005125 cytokine activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL16 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL16 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL16 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL16 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL16 in various data sets.
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Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL16. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL16. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL16. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL16. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL16 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL16 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL16 |
Name | interleukin 16 |
Aliases | LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806; prointerleukin 16; lymphocyte chemoattractant factor; int ...... |
Chromosomal Location | 15q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL16 collected from DrugBank database. |
There is no record. |