Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF06083 Interleukin-17 |
Function |
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002521 leukocyte differentiation GO:0002532 production of molecular mediator involved in inflammatory response GO:0002534 cytokine production involved in inflammatory response GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0009306 protein secretion GO:0009620 response to fungus GO:0030099 myeloid cell differentiation GO:0030316 osteoclast differentiation GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032627 interleukin-23 production GO:0032635 interleukin-6 production GO:0032667 regulation of interleukin-23 production GO:0032675 regulation of interleukin-6 production GO:0032747 positive regulation of interleukin-23 production GO:0032755 positive regulation of interleukin-6 production GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045672 positive regulation of osteoclast differentiation GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050832 defense response to fungus GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0070555 response to interleukin-1 GO:0071347 cellular response to interleukin-1 GO:0072537 fibroblast activation GO:0072604 interleukin-6 secretion GO:0098542 defense response to other organism GO:1900015 regulation of cytokine production involved in inflammatory response GO:1900017 positive regulation of cytokine production involved in inflammatory response GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903532 positive regulation of secretion by cell GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904951 positive regulation of establishment of protein localization GO:2000778 positive regulation of interleukin-6 secretion |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-448424: Interleukin-17 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL17A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL17A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL17A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL17A in various data sets.
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Points in the above scatter plot represent the mutation difference of IL17A in various data sets.
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Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL17A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL17A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL17A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL17A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL17A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL17A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL17A |
Name | interleukin 17A |
Aliases | IL-17A; IL-17; cytotoxic T-lymphocyte-associated protein 8; CTLA8; IL17; interleukin 17 (cytotoxic T-lymphoc ...... |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL17A collected from DrugBank database. |
Details on drugs targeting IL17A.
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