Summary | |
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Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain | - |
Function |
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0006979 response to oxidative stress GO:0010035 response to inorganic substance GO:0032496 response to lipopolysaccharide GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0042088 T-helper 1 type immune response GO:0042542 response to hydrogen peroxide GO:0070301 cellular response to hydrogen peroxide GO:0071356 cellular response to tumor necrosis factor GO:1900115 extracellular regulation of signal transduction GO:1900116 extracellular negative regulation of signal transduction |
Molecular Function |
GO:0019955 cytokine binding GO:0030545 receptor regulator activity GO:0030547 receptor inhibitor activity GO:0042007 interleukin-18 binding GO:0048019 receptor antagonist activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL18BP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL18BP and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL18BP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL18BP in various data sets.
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Points in the above scatter plot represent the mutation difference of IL18BP in various data sets.
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Summary | |
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Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL18BP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL18BP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL18BP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL18BP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL18BP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL18BP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IL18BP |
Name | interleukin 18 binding protein |
Aliases | IL18BPa; MC51L-53L-54L homolog gene product; IL-18BP; tadekinig-alfa; Interleukin-18-binding protein |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL18BP collected from DrugBank database. |
There is no record. |