Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol Lysosome Secreted, exosome Secreted Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood (PubMed:24201029). On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (PubMed:15192144). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (PubMed:24201029). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (By similarity). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (PubMed:11728343). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (By similarity). These mechanisms may not be not mutually exclusive. |
Domain |
PF00340 Interleukin-1 / 18 PF02394 Interleukin-1 propeptide |
Function |
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001525 angiogenesis GO:0001659 temperature homeostasis GO:0001660 fever generation GO:0001819 positive regulation of cytokine production GO:0001885 endothelial cell development GO:0001933 negative regulation of protein phosphorylation GO:0002064 epithelial cell development GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002526 acute inflammatory response GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0003012 muscle system process GO:0003158 endothelium development GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006066 alcohol metabolic process GO:0006469 negative regulation of protein kinase activity GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006509 membrane protein ectodomain proteolysis GO:0006606 protein import into nucleus GO:0006611 protein export from nucleus GO:0006694 steroid biosynthetic process GO:0006766 vitamin metabolic process GO:0006775 fat-soluble vitamin metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006820 anion transport GO:0006869 lipid transport GO:0006909 phagocytosis GO:0006913 nucleocytoplasmic transport GO:0006953 acute-phase response GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007159 leukocyte cell-cell adhesion GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0007346 regulation of mitotic cell cycle GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0008202 steroid metabolic process GO:0008286 insulin receptor signaling pathway GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009110 vitamin biosynthetic process GO:0009306 protein secretion GO:0009612 response to mechanical stimulus GO:0009743 response to carbohydrate GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009914 hormone transport GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010623 programmed cell death involved in cell development GO:0010817 regulation of hormone levels GO:0010827 regulation of glucose transport GO:0010829 negative regulation of glucose transport GO:0010876 lipid localization GO:0010893 positive regulation of steroid biosynthetic process GO:0014074 response to purine-containing compound GO:0014805 smooth muscle adaptation GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015732 prostaglandin transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0015833 peptide transport GO:0015908 fatty acid transport GO:0016042 lipid catabolic process GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0016573 histone acetylation GO:0017038 protein import GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0019915 lipid storage GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030100 regulation of endocytosis GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030213 hyaluronan biosynthetic process GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0030656 regulation of vitamin metabolic process GO:0030730 sequestering of triglyceride GO:0030856 regulation of epithelial cell differentiation GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031098 stress-activated protein kinase signaling cascade GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031349 positive regulation of defense response GO:0031503 protein complex localization GO:0031620 regulation of fever generation GO:0031622 positive regulation of fever generation GO:0031649 heat generation GO:0031650 regulation of heat generation GO:0031652 positive regulation of heat generation GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032303 regulation of icosanoid secretion GO:0032305 positive regulation of icosanoid secretion GO:0032306 regulation of prostaglandin secretion GO:0032308 positive regulation of prostaglandin secretion GO:0032309 icosanoid secretion GO:0032310 prostaglandin secretion GO:0032368 regulation of lipid transport GO:0032370 positive regulation of lipid transport GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032604 granulocyte macrophage colony-stimulating factor production GO:0032609 interferon-gamma production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032623 interleukin-2 production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032642 regulation of chemokine production GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production GO:0032649 regulation of interferon-gamma production GO:0032663 regulation of interleukin-2 production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032722 positive regulation of chemokine production GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032729 positive regulation of interferon-gamma production GO:0032743 positive regulation of interleukin-2 production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0032768 regulation of monooxygenase activity GO:0032770 positive regulation of monooxygenase activity GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033127 regulation of histone phosphorylation GO:0033129 positive regulation of histone phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033198 response to ATP GO:0033619 membrane protein proteolysis GO:0033673 negative regulation of kinase activity GO:0033674 positive regulation of kinase activity GO:0034113 heterotypic cell-cell adhesion GO:0034114 regulation of heterotypic cell-cell adhesion GO:0034116 positive regulation of heterotypic cell-cell adhesion GO:0034504 protein localization to nucleus GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035234 ectopic germ cell programmed cell death GO:0035504 regulation of myosin light chain kinase activity GO:0035505 positive regulation of myosin light chain kinase activity GO:0035690 cellular response to drug GO:0038034 signal transduction in absence of ligand GO:0042033 chemokine biosynthetic process GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042094 interleukin-2 biosynthetic process GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042176 regulation of protein catabolic process GO:0042226 interleukin-6 biosynthetic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042345 regulation of NF-kappaB import into nucleus GO:0042346 positive regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042359 vitamin D metabolic process GO:0042362 fat-soluble vitamin biosynthetic process GO:0042368 vitamin D biosynthetic process GO:0042493 response to drug GO:0042886 amide transport GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043270 positive regulation of ion transport GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043491 protein kinase B signaling GO:0043500 muscle adaptation GO:0043543 protein acylation GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044070 regulation of anion transport GO:0044283 small molecule biosynthetic process GO:0044706 multi-multicellular organism process GO:0044744 protein targeting to nucleus GO:0045073 regulation of chemokine biosynthetic process GO:0045076 regulation of interleukin-2 biosynthetic process GO:0045080 positive regulation of chemokine biosynthetic process GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045408 regulation of interleukin-6 biosynthetic process GO:0045410 positive regulation of interleukin-6 biosynthetic process GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045446 endothelial cell differentiation GO:0045601 regulation of endothelial cell differentiation GO:0045732 positive regulation of protein catabolic process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045785 positive regulation of cell adhesion GO:0045787 positive regulation of cell cycle GO:0045807 positive regulation of endocytosis GO:0045833 negative regulation of lipid metabolic process GO:0045834 positive regulation of lipid metabolic process GO:0045840 positive regulation of mitotic nuclear division GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0045931 positive regulation of mitotic cell cycle GO:0045940 positive regulation of steroid metabolic process GO:0046136 positive regulation of vitamin metabolic process GO:0046165 alcohol biosynthetic process GO:0046209 nitric oxide metabolic process GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046626 regulation of insulin receptor signaling pathway GO:0046627 negative regulation of insulin receptor signaling pathway GO:0046651 lymphocyte proliferation GO:0046683 response to organophosphorus GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046827 positive regulation of protein export from nucleus GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0046942 carboxylic acid transport GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048514 blood vessel morphogenesis GO:0048871 multicellular organismal homeostasis GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050755 chemokine metabolic process GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050796 regulation of insulin secretion GO:0050810 regulation of steroid biosynthetic process GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050886 endocrine process GO:0050900 leukocyte migration GO:0050994 regulation of lipid catabolic process GO:0050995 negative regulation of lipid catabolic process GO:0050996 positive regulation of lipid catabolic process GO:0050999 regulation of nitric-oxide synthase activity GO:0051043 regulation of membrane protein ectodomain proteolysis GO:0051044 positive regulation of membrane protein ectodomain proteolysis GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051235 maintenance of location GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051302 regulation of cell division GO:0051341 regulation of oxidoreductase activity GO:0051348 negative regulation of transferase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051403 stress-activated MAPK cascade GO:0051781 positive regulation of cell division GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0060326 cell chemotaxis GO:0060352 cell adhesion molecule production GO:0060353 regulation of cell adhesion molecule production GO:0060355 positive regulation of cell adhesion molecule production GO:0060556 regulation of vitamin D biosynthetic process GO:0060557 positive regulation of vitamin D biosynthetic process GO:0060558 regulation of calcidiol 1-monooxygenase activity GO:0060559 positive regulation of calcidiol 1-monooxygenase activity GO:0060627 regulation of vesicle-mediated transport GO:0060986 endocrine hormone secretion GO:0061028 establishment of endothelial barrier GO:0070162 adiponectin secretion GO:0070163 regulation of adiponectin secretion GO:0070164 negative regulation of adiponectin secretion GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070486 leukocyte aggregation GO:0070487 monocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0071605 monocyte chemotactic protein-1 production GO:0071621 granulocyte chemotaxis GO:0071637 regulation of monocyte chemotactic protein-1 production GO:0071639 positive regulation of monocyte chemotactic protein-1 production GO:0071715 icosanoid transport GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072593 reactive oxygen species metabolic process GO:0072604 interleukin-6 secretion GO:0090068 positive regulation of cell cycle process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090287 regulation of cellular response to growth factor stimulus GO:0090316 positive regulation of intracellular protein transport GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1900076 regulation of cellular response to insulin stimulus GO:1900077 negative regulation of cellular response to insulin stimulus GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901099 negative regulation of signal transduction in absence of ligand GO:1901342 regulation of vasculature development GO:1901550 regulation of endothelial cell development GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902275 regulation of chromatin organization GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1902930 regulation of alcohol biosynthetic process GO:1902932 positive regulation of alcohol biosynthetic process GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903140 regulation of establishment of endothelial barrier GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903510 mucopolysaccharide metabolic process GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903793 positive regulation of anion transport GO:1903829 positive regulation of cellular protein localization GO:1904018 positive regulation of vasculature development GO:1904407 positive regulation of nitric oxide metabolic process GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:1905269 positive regulation of chromatin organization GO:1990266 neutrophil migration GO:2000191 regulation of fatty acid transport GO:2000193 positive regulation of fatty acid transport GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation GO:2000778 positive regulation of interleukin-6 secretion GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005149 interleukin-1 receptor binding GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0005776 autophagosome GO:0030141 secretory granule GO:0099503 secretory vesicle |
KEGG |
hsa04010 MAPK signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04064 NF-kappa B signaling pathway hsa04380 Osteoclast differentiation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04640 Hematopoietic cell lineage hsa04668 TNF signaling pathway hsa04750 Inflammatory mediator regulation of TRP channels |
Reactome |
R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-5660668: CLEC7A/inflammasome pathway R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-448706: Interleukin-1 processing R-HSA-446652: Interleukin-1 signaling R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL1B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL1B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL1B in various data sets.
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Points in the above scatter plot represent the mutation difference of IL1B in various data sets.
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Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL1B |
Name | interleukin 1, beta |
Aliases | IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL1B collected from DrugBank database. |
Details on drugs targeting IL1B.
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