Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform C: Cell membrane.; SUBCELLULAR LOCATION: Isoform B: Secreted.; SUBCELLULAR LOCATION: Cell membrane Single-pass type I membrane protein |
Domain |
PF07679 Immunoglobulin I-set domain PF01582 TIR domain |
Function |
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. ; FUNCTION: Isoform B: Inhibits IL-33 signaling. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002250 adaptive immune response GO:0002274 myeloid leukocyte activation GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002825 regulation of T-helper 1 type immune response GO:0002826 negative regulation of T-helper 1 type immune response GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0009306 protein secretion GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032602 chemokine production GO:0032609 interferon-gamma production GO:0032634 interleukin-5 production GO:0032642 regulation of chemokine production GO:0032649 regulation of interferon-gamma production GO:0032674 regulation of interleukin-5 production GO:0032689 negative regulation of interferon-gamma production GO:0032722 positive regulation of chemokine production GO:0032754 positive regulation of interleukin-5 production GO:0038172 interleukin-33-mediated signaling pathway GO:0042088 T-helper 1 type immune response GO:0042116 macrophage activation GO:0043030 regulation of macrophage activation GO:0043032 positive regulation of macrophage activation GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050777 negative regulation of immune response GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0090195 chemokine secretion GO:0090196 regulation of chemokine secretion GO:0090197 positive regulation of chemokine secretion GO:1902532 negative regulation of intracellular signal transduction GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0002113 interleukin-33 binding GO:0002114 interleukin-33 receptor activity GO:0004896 cytokine receptor activity GO:0004908 interleukin-1 receptor activity GO:0005057 receptor signaling protein activity GO:0019955 cytokine binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL1RL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL1RL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL1RL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL1RL1 in various data sets.
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Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1RL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1RL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1RL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1RL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL1RL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL1RL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IL1RL1 |
Name | interleukin 1 receptor-like 1 |
Aliases | FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ...... |
Chromosomal Location | 2q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL1RL1 collected from DrugBank database. |
There is no record. |