Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00715 Interleukin 2 |
Function |
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0001558 regulation of cell growth GO:0001776 leukocyte homeostasis GO:0001777 T cell homeostatic proliferation GO:0001783 B cell apoptotic process GO:0001819 positive regulation of cytokine production GO:0001933 negative regulation of protein phosphorylation GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002250 adaptive immune response GO:0002260 lymphocyte homeostasis GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0002902 regulation of B cell apoptotic process GO:0002903 negative regulation of B cell apoptotic process GO:0003013 circulatory system process GO:0003015 heart process GO:0006310 DNA recombination GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007159 leukocyte cell-cell adhesion GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009306 protein secretion GO:0010720 positive regulation of cell development GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016049 cell growth GO:0016064 immunoglobulin mediated immune response GO:0016358 dendrite development GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019724 B cell mediated immunity GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030101 natural killer cell activation GO:0030217 T cell differentiation GO:0030307 positive regulation of cell growth GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031346 positive regulation of cell projection organization GO:0031348 negative regulation of defense response GO:0031349 positive regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032609 interferon-gamma production GO:0032620 interleukin-17 production GO:0032649 regulation of interferon-gamma production GO:0032660 regulation of interleukin-17 production GO:0032729 positive regulation of interferon-gamma production GO:0032740 positive regulation of interleukin-17 production GO:0032844 regulation of homeostatic process GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0034103 regulation of tissue remodeling GO:0034105 positive regulation of tissue remodeling GO:0038034 signal transduction in absence of ligand GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042104 positive regulation of activated T cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042129 regulation of T cell proliferation GO:0042326 negative regulation of phosphorylation GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043029 T cell homeostasis GO:0044057 regulation of system process GO:0045066 regulatory T cell differentiation GO:0045190 isotype switching GO:0045191 regulation of isotype switching GO:0045471 response to ethanol GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045589 regulation of regulatory T cell differentiation GO:0045591 positive regulation of regulatory T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045666 positive regulation of neuron differentiation GO:0045785 positive regulation of cell adhesion GO:0045822 negative regulation of heart contraction GO:0045830 positive regulation of isotype switching GO:0045911 positive regulation of DNA recombination GO:0045927 positive regulation of growth GO:0046006 regulation of activated T cell proliferation GO:0046013 regulation of T cell homeostatic proliferation GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046651 lymphocyte proliferation GO:0048291 isotype switching to IgG isotypes GO:0048302 regulation of isotype switching to IgG isotypes GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0048305 immunoglobulin secretion GO:0048771 tissue remodeling GO:0048872 homeostasis of number of cells GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050798 activated T cell proliferation GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0051023 regulation of immunoglobulin secretion GO:0051024 positive regulation of immunoglobulin secretion GO:0051047 positive regulation of secretion GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051480 regulation of cytosolic calcium ion concentration GO:0051962 positive regulation of nervous system development GO:0055074 calcium ion homeostasis GO:0060047 heart contraction GO:0060996 dendritic spine development GO:0060998 regulation of dendritic spine development GO:0060999 positive regulation of dendritic spine development GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070229 negative regulation of lymphocyte apoptotic process GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071887 leukocyte apoptotic process GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097305 response to alcohol GO:0097696 STAT cascade GO:1900006 positive regulation of dendrite development GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903522 regulation of blood circulation GO:1903523 negative regulation of blood circulation GO:1903532 positive regulation of secretion by cell GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1904951 positive regulation of establishment of protein localization GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005134 interleukin-2 receptor binding GO:0008047 enzyme activator activity GO:0008083 growth factor activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0030246 carbohydrate binding GO:0031628 opioid receptor binding GO:0031851 kappa-type opioid receptor binding GO:0043208 glycosphingolipid binding GO:0046625 sphingolipid binding GO:0051861 glycolipid binding GO:0070851 growth factor receptor binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04660 T cell receptor signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL2 in various data sets.
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Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL2 |
Name | interleukin 2 |
Aliases | IL-2; TCGF; T cell growth factor; lymphokine; aldesleukin; involved in regulation of T-cell clonal expansion ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL2 collected from DrugBank database. |
Details on drugs targeting IL2.
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