Browse IL22

Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF14565 Interleukin 22 IL-10-related T-cell-derived-inducible factor
Function

Cytokine that contributes to the inflammatory response in vivo.

> Gene Ontology
 
Biological Process GO:0002526 acute inflammatory response
GO:0006953 acute-phase response
GO:0007259 JAK-STAT cascade
GO:0031960 response to corticosteroid
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
GO:0097696 STAT cascade
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0045518 interleukin-22 receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
hsa04630 Jak-STAT signaling pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-8854691: Interleukin-19, 20, 22, 24
R-HSA-449147: Signaling by Interleukins
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IL22 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IL22 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29764837Lung CarcinomaPromote immunityWe then showed that genetic ablation of Il22 in CC-LR mice (CC-LR/IL22KO mice) caused a significant reduction in tumor number and size. This was accompanied by significantly lower tumor cell proliferation, angiogenesis, and STAT3 activation. Il22 ablation was also associated with significant reduction in lung-infiltrating inflammatory cells and expression of protumor inflammatory cytokines. Thus, we conclude that IL22 promotes Kras-mutant lung tumorigenesis by driving a protumor inflammatory microenvironment with proliferative, angiogenic, and stemness contextual cues in epithelial/tumor cells.
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IL22 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IL22 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3740.707
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0030.496
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.120.191
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0630.628
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IL22 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL22. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL22. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL22.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL22. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IL22 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IL22 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIL22
Nameinterleukin 22
Aliases ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IL22 collected from DrugBank database.
> Drugs from DrugBank database
 

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