Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF14565 Interleukin 22 IL-10-related T-cell-derived-inducible factor |
Function |
Cytokine that contributes to the inflammatory response in vivo. |
Biological Process |
GO:0002526 acute inflammatory response GO:0006953 acute-phase response GO:0007259 JAK-STAT cascade GO:0031960 response to corticosteroid GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0048545 response to steroid hormone GO:0051384 response to glucocorticoid GO:0097696 STAT cascade GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0045518 interleukin-22 receptor binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-8854691: Interleukin-19, 20, 22, 24 R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL22 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL22 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL22 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL22 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL22 in various data sets.
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Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL22. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL22. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL22. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL22. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL22 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL22 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL22 |
Name | interleukin 22 |
Aliases | ILTIF; zcyto18; IL-TIF; IL-D110; TIFIL-23; MGC79382; MGC79384; IL-10-related T-cell-derived inducible factor ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL22 collected from DrugBank database. |
There is no record. |