Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain | - |
Function |
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
Biological Process |
GO:0001787 natural killer cell proliferation GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0001914 regulation of T cell mediated cytotoxicity GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0002230 positive regulation of defense response to virus by host GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002295 T-helper cell lineage commitment GO:0002360 T cell lineage commitment GO:0002363 alpha-beta T cell lineage commitment GO:0002366 leukocyte activation involved in immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002825 regulation of T-helper 1 type immune response GO:0002827 positive regulation of T-helper 1 type immune response GO:0002831 regulation of response to biotic stimulus GO:0007159 leukocyte cell-cell adhesion GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0009615 response to virus GO:0010453 regulation of cell fate commitment GO:0010455 positive regulation of cell fate commitment GO:0010533 regulation of activation of Janus kinase activity GO:0010534 regulation of activation of JAK2 kinase activity GO:0010535 positive regulation of activation of JAK2 kinase activity GO:0010536 positive regulation of activation of Janus kinase activity GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030101 natural killer cell activation GO:0030217 T cell differentiation GO:0030316 osteoclast differentiation GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0032147 activation of protein kinase activity GO:0032496 response to lipopolysaccharide GO:0032604 granulocyte macrophage colony-stimulating factor production GO:0032609 interferon-gamma production GO:0032613 interleukin-10 production GO:0032615 interleukin-12 production GO:0032620 interleukin-17 production GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production GO:0032649 regulation of interferon-gamma production GO:0032653 regulation of interleukin-10 production GO:0032655 regulation of interleukin-12 production GO:0032660 regulation of interleukin-17 production GO:0032693 negative regulation of interleukin-10 production GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032729 positive regulation of interferon-gamma production GO:0032735 positive regulation of interleukin-12 production GO:0032740 positive regulation of interleukin-17 production GO:0032814 regulation of natural killer cell activation GO:0032816 positive regulation of natural killer cell activation GO:0032817 regulation of natural killer cell proliferation GO:0032819 positive regulation of natural killer cell proliferation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033674 positive regulation of kinase activity GO:0034341 response to interferon-gamma GO:0035710 CD4-positive, alpha-beta T cell activation GO:0038155 interleukin-23-mediated signaling pathway GO:0042088 T-helper 1 type immune response GO:0042093 T-helper cell differentiation GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042104 positive regulation of activated T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042504 tyrosine phosphorylation of Stat4 protein GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042508 tyrosine phosphorylation of Stat1 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042519 regulation of tyrosine phosphorylation of Stat4 protein GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042742 defense response to bacterium GO:0042976 activation of Janus kinase activity GO:0042977 activation of JAK2 kinase activity GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043368 positive T cell selection GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043373 CD4-positive, alpha-beta T cell lineage commitment GO:0043379 memory T cell differentiation GO:0043380 regulation of memory T cell differentiation GO:0043382 positive regulation of memory T cell differentiation GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0045058 T cell selection GO:0045165 cell fate commitment GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045622 regulation of T-helper cell differentiation GO:0045624 positive regulation of T-helper cell differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045672 positive regulation of osteoclast differentiation GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0046006 regulation of activated T cell proliferation GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050688 regulation of defense response to virus GO:0050691 regulation of defense response to virus by host GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050792 regulation of viral process GO:0050798 activated T cell proliferation GO:0050829 defense response to Gram-negative bacterium GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051132 NK T cell activation GO:0051133 regulation of NK T cell activation GO:0051135 positive regulation of NK T cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051607 defense response to virus GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0072538 T-helper 17 type immune response GO:0072539 T-helper 17 cell differentiation GO:0072540 T-helper 17 cell lineage commitment GO:0097696 STAT cascade GO:0098542 defense response to other organism GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000316 regulation of T-helper 17 type immune response GO:2000318 positive regulation of T-helper 17 type immune response GO:2000319 regulation of T-helper 17 cell differentiation GO:2000321 positive regulation of T-helper 17 cell differentiation GO:2000328 regulation of T-helper 17 cell lineage commitment GO:2000330 positive regulation of T-helper 17 cell lineage commitment GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0005126 cytokine receptor binding GO:0005143 interleukin-12 receptor binding GO:0019955 cytokine binding GO:0042019 interleukin-23 binding GO:0042020 interleukin-23 receptor activity GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0043235 receptor complex GO:0072536 interleukin-23 receptor complex GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL23R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL23R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL23R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL23R in various data sets.
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Points in the above scatter plot represent the mutation difference of IL23R in various data sets.
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Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL23R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL23R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL23R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL23R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL23R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL23R |
Name | interleukin 23 receptor |
Aliases | IL-23R; IL-23 receptor; Interleukin-23 receptor |
Chromosomal Location | 1p31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL23R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |