Summary | |
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Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain | - |
Function |
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0030336 negative regulation of cell migration GO:0032496 response to lipopolysaccharide GO:0033136 serine phosphorylation of STAT3 protein GO:0040013 negative regulation of locomotion GO:0042501 serine phosphorylation of STAT protein GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051271 negative regulation of cellular component movement GO:0070670 response to interleukin-4 GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071353 cellular response to interleukin-4 GO:0071396 cellular response to lipid GO:0097696 STAT cascade GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0005125 cytokine activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-8854691: Interleukin-19, 20, 22, 24 R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL24 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL24 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL24 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL24 in various data sets.
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Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL24. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL24. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL24. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL24. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL24 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL24 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IL24 |
Name | interleukin 24 |
Aliases | mda-7; IL10B; Mob-5; C49A; FISP; IL-24; melanoma differentiation association protein 7; suppression of tumor ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL24 collected from DrugBank database. |
There is no record. |