Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF00084 Sushi repeat (SCR repeat) |
Function |
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. |
Biological Process |
GO:0001776 leukocyte homeostasis GO:0001777 T cell homeostatic proliferation GO:0002260 lymphocyte homeostasis GO:0002437 inflammatory response to antigenic stimulus GO:0002507 tolerance induction GO:0002517 T cell tolerance induction GO:0002521 leukocyte differentiation GO:0002643 regulation of tolerance induction GO:0002664 regulation of T cell tolerance induction GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0006924 activation-induced cell death of T cells GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007219 Notch signaling pathway GO:0009615 response to virus GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0031348 negative regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032844 regulation of homeostatic process GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0038110 interleukin-2-mediated signaling pathway GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042104 positive regulation of activated T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0043029 T cell homeostasis GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0046006 regulation of activated T cell proliferation GO:0046013 regulation of T cell homeostatic proliferation GO:0046651 lymphocyte proliferation GO:0048525 negative regulation of viral process GO:0048872 homeostasis of number of cells GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050687 negative regulation of defense response to virus GO:0050688 regulation of defense response to virus GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050777 negative regulation of immune response GO:0050792 regulation of viral process GO:0050798 activated T cell proliferation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051607 defense response to virus GO:0070227 lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0070669 response to interleukin-2 GO:0071352 cellular response to interleukin-2 GO:0071593 lymphocyte aggregation GO:0071887 leukocyte apoptotic process GO:0098542 defense response to other organism GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004911 interleukin-2 receptor activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0008144 drug binding GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0019976 interleukin-2 binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04144 Endocytosis hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL2RA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL2RA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL2RA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL2RA in various data sets.
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Points in the above scatter plot represent the mutation difference of IL2RA in various data sets.
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Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL2RA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL2RA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL2RA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL2RA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL2RA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL2RA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL2RA |
Name | interleukin 2 receptor, alpha |
Aliases | IL2R; IDDM10; insulin-dependent diabetes mellitus 10; TCGFR; IL-2 receptor subunit alpha; IL-2R subunit alph ...... |
Chromosomal Location | 10p15-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL2RA collected from DrugBank database. |
Details on drugs targeting IL2RA.
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