Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF15036 Interleukin 34 |
Function |
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
Biological Process |
GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0030225 macrophage differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045649 regulation of macrophage differentiation GO:0045651 positive regulation of macrophage differentiation GO:0045655 regulation of monocyte differentiation GO:0045657 positive regulation of monocyte differentiation GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903131 mononuclear cell differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005157 macrophage colony-stimulating factor receptor binding GO:0008083 growth factor activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL34 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL34 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL34 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL34 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL34 in various data sets.
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Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL34. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL34. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL34. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL34. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL34 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL34 |
Name | interleukin 34 |
Aliases | MGC34647; IL-34; C16orf77; chromosome 16 open reading frame 77; Interleukin-34 |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL34 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |