Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00727 Interleukin 4 |
Function |
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0000768 syncytium formation by plasma membrane fusion GO:0001562 response to protozoan GO:0001654 eye development GO:0001667 ameboidal-type cell migration GO:0001773 myeloid dendritic cell activation GO:0001774 microglial cell activation GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002227 innate immune response in mucosa GO:0002230 positive regulation of defense response to virus by host GO:0002250 adaptive immune response GO:0002251 organ or tissue specific immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002279 mast cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002295 T-helper cell lineage commitment GO:0002296 T-helper 1 cell lineage commitment GO:0002312 B cell activation involved in immune response GO:0002360 T cell lineage commitment GO:0002363 alpha-beta T cell lineage commitment GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002369 T cell cytokine production GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002385 mucosal immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002526 acute inflammatory response GO:0002544 chronic inflammatory response GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002573 myeloid leukocyte differentiation GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002673 regulation of acute inflammatory response GO:0002674 negative regulation of acute inflammatory response GO:0002676 regulation of chronic inflammatory response GO:0002677 negative regulation of chronic inflammatory response GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002761 regulation of myeloid leukocyte differentiation GO:0002762 negative regulation of myeloid leukocyte differentiation GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002831 regulation of response to biotic stimulus GO:0002886 regulation of myeloid leukocyte mediated immunity GO:0002888 positive regulation of myeloid leukocyte mediated immunity GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0006066 alcohol metabolic process GO:0006310 DNA recombination GO:0006809 nitric oxide biosynthetic process GO:0006818 hydrogen transport GO:0006887 exocytosis GO:0006949 syncytium formation GO:0006968 cellular defense response GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007423 sensory organ development GO:0007520 myoblast fusion GO:0007565 female pregnancy GO:0007584 response to nutrient GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0009615 response to virus GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010155 regulation of proton transport GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010830 regulation of myotube differentiation GO:0010831 positive regulation of myotube differentiation GO:0014902 myotube differentiation GO:0015672 monovalent inorganic cation transport GO:0015992 proton transport GO:0016064 immunoglobulin mediated immune response GO:0016125 sterol metabolic process GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0017157 regulation of exocytosis GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019724 B cell mediated immunity GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0030316 osteoclast differentiation GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031294 lymphocyte costimulation GO:0031296 B cell costimulation GO:0031341 regulation of cell killing GO:0031342 negative regulation of cell killing GO:0031348 negative regulation of defense response GO:0031667 response to nutrient levels GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032418 lysosome localization GO:0032601 connective tissue growth factor production GO:0032602 chemokine production GO:0032613 interleukin-10 production GO:0032616 interleukin-13 production GO:0032642 regulation of chemokine production GO:0032653 regulation of interleukin-10 production GO:0032656 regulation of interleukin-13 production GO:0032722 positive regulation of chemokine production GO:0032733 positive regulation of interleukin-10 production GO:0032736 positive regulation of interleukin-13 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033003 regulation of mast cell activation GO:0033005 positive regulation of mast cell activation GO:0033006 regulation of mast cell activation involved in immune response GO:0033008 positive regulation of mast cell activation involved in immune response GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035743 CD4-positive, alpha-beta T cell cytokine production GO:0035745 T-helper 2 cell cytokine production GO:0038034 signal transduction in absence of ligand GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0042033 chemokine biosynthetic process GO:0042035 regulation of cytokine biosynthetic process GO:0042088 T-helper 1 type immune response GO:0042089 cytokine biosynthetic process GO:0042092 type 2 immune response GO:0042093 T-helper cell differentiation GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042104 positive regulation of activated T cell proliferation GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042110 T cell activation GO:0042113 B cell activation GO:0042116 macrophage activation GO:0042129 regulation of T cell proliferation GO:0042493 response to drug GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042692 muscle cell differentiation GO:0042832 defense response to protozoan GO:0043010 camera-type eye development GO:0043011 myeloid dendritic cell differentiation GO:0043030 regulation of macrophage activation GO:0043031 negative regulation of macrophage activation GO:0043299 leukocyte degranulation GO:0043300 regulation of leukocyte degranulation GO:0043302 positive regulation of leukocyte degranulation GO:0043303 mast cell degranulation GO:0043304 regulation of mast cell degranulation GO:0043306 positive regulation of mast cell degranulation GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043368 positive T cell selection GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation GO:0043373 CD4-positive, alpha-beta T cell lineage commitment GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044706 multi-multicellular organism process GO:0045019 negative regulation of nitric oxide biosynthetic process GO:0045055 regulated exocytosis GO:0045058 T cell selection GO:0045063 T-helper 1 cell differentiation GO:0045064 T-helper 2 cell differentiation GO:0045073 regulation of chemokine biosynthetic process GO:0045080 positive regulation of chemokine biosynthetic process GO:0045165 cell fate commitment GO:0045189 connective tissue growth factor biosynthetic process GO:0045190 isotype switching GO:0045191 regulation of isotype switching GO:0045342 MHC class II biosynthetic process GO:0045346 regulation of MHC class II biosynthetic process GO:0045348 positive regulation of MHC class II biosynthetic process GO:0045428 regulation of nitric oxide biosynthetic process GO:0045471 response to ethanol GO:0045576 mast cell activation GO:0045580 regulation of T cell differentiation GO:0045581 negative regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045620 negative regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045622 regulation of T-helper cell differentiation GO:0045623 negative regulation of T-helper cell differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045671 negative regulation of osteoclast differentiation GO:0045785 positive regulation of cell adhesion GO:0045830 positive regulation of isotype switching GO:0045911 positive regulation of DNA recombination GO:0045921 positive regulation of exocytosis GO:0046006 regulation of activated T cell proliferation GO:0046209 nitric oxide metabolic process GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046636 negative regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046639 negative regulation of alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0046689 response to mercury ion GO:0048245 eosinophil chemotaxis GO:0048289 isotype switching to IgE isotypes GO:0048291 isotype switching to IgG isotypes GO:0048293 regulation of isotype switching to IgE isotypes GO:0048295 positive regulation of isotype switching to IgE isotypes GO:0048302 regulation of isotype switching to IgG isotypes GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050688 regulation of defense response to virus GO:0050691 regulation of defense response to virus by host GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050755 chemokine metabolic process GO:0050777 negative regulation of immune response GO:0050792 regulation of viral process GO:0050798 activated T cell proliferation GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051047 positive regulation of secretion GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051607 defense response to virus GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0060041 retina development in camera-type eye GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:0060326 cell chemotaxis GO:0060627 regulation of vesicle-mediated transport GO:0070341 fat cell proliferation GO:0070343 white fat cell proliferation GO:0070344 regulation of fat cell proliferation GO:0070345 negative regulation of fat cell proliferation GO:0070350 regulation of white fat cell proliferation GO:0070351 negative regulation of white fat cell proliferation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071288 cellular response to mercury ion GO:0071593 lymphocyte aggregation GO:0071621 granulocyte chemotaxis GO:0071622 regulation of granulocyte chemotaxis GO:0071624 positive regulation of granulocyte chemotaxis GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0072538 T-helper 17 type immune response GO:0072539 T-helper 17 cell differentiation GO:0072577 endothelial cell apoptotic process GO:0072593 reactive oxygen species metabolic process GO:0072677 eosinophil migration GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097028 dendritic cell differentiation GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097278 complement-dependent cytotoxicity GO:0097305 response to alcohol GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:0097696 STAT cascade GO:0098542 defense response to other organism GO:1901615 organic hydroxy compound metabolic process GO:1901739 regulation of myoblast fusion GO:1901741 positive regulation of myoblast fusion GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902652 secondary alcohol metabolic process GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903305 regulation of regulated secretory pathway GO:1903307 positive regulation of regulated secretory pathway GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903532 positive regulation of secretion by cell GO:1903659 regulation of complement-dependent cytotoxicity GO:1903660 negative regulation of complement-dependent cytotoxicity GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:1904406 negative regulation of nitric oxide metabolic process GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1990267 response to transition metal nanoparticle GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000316 regulation of T-helper 17 type immune response GO:2000317 negative regulation of T-helper 17 type immune response GO:2000319 regulation of T-helper 17 cell differentiation GO:2000320 negative regulation of T-helper 17 cell differentiation GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000416 regulation of eosinophil migration GO:2000418 positive regulation of eosinophil migration GO:2000422 regulation of eosinophil chemotaxis GO:2000424 positive regulation of eosinophil chemotaxis GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005136 interleukin-4 receptor binding GO:0008083 growth factor activity GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage hsa04660 T cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL4 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL4 in various data sets.
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Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL4 |
Name | interleukin 4 |
Aliases | BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; B cell gr ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL4 collected from DrugBank database. |
Details on drugs targeting IL4.
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