Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted. |
Domain |
PF09238 Interleukin-4 receptor alpha chain |
Function |
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. ; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001562 response to protozoan GO:0001819 positive regulation of cytokine production GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002279 mast cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002532 production of molecular mediator involved in inflammatory response GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002825 regulation of T-helper 1 type immune response GO:0002826 negative regulation of T-helper 1 type immune response GO:0002828 regulation of type 2 immune response GO:0002830 positive regulation of type 2 immune response GO:0002886 regulation of myeloid leukocyte mediated immunity GO:0002888 positive regulation of myeloid leukocyte mediated immunity GO:0006887 exocytosis GO:0006949 syncytium formation GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007292 female gamete generation GO:0007520 myoblast fusion GO:0009306 protein secretion GO:0010830 regulation of myotube differentiation GO:0010831 positive regulation of myotube differentiation GO:0014902 myotube differentiation GO:0016064 immunoglobulin mediated immune response GO:0017157 regulation of exocytosis GO:0019724 B cell mediated immunity GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030728 ovulation GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032418 lysosome localization GO:0032602 chemokine production GO:0032642 regulation of chemokine production GO:0032722 positive regulation of chemokine production GO:0033003 regulation of mast cell activation GO:0033005 positive regulation of mast cell activation GO:0033006 regulation of mast cell activation involved in immune response GO:0033008 positive regulation of mast cell activation involved in immune response GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035771 interleukin-4-mediated signaling pathway GO:0042088 T-helper 1 type immune response GO:0042092 type 2 immune response GO:0042093 T-helper cell differentiation GO:0042110 T cell activation GO:0042116 macrophage activation GO:0042692 muscle cell differentiation GO:0042832 defense response to protozoan GO:0043030 regulation of macrophage activation GO:0043032 positive regulation of macrophage activation GO:0043299 leukocyte degranulation GO:0043300 regulation of leukocyte degranulation GO:0043302 positive regulation of leukocyte degranulation GO:0043303 mast cell degranulation GO:0043304 regulation of mast cell degranulation GO:0043306 positive regulation of mast cell degranulation GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043627 response to estrogen GO:0045055 regulated exocytosis GO:0045063 T-helper 1 cell differentiation GO:0045064 T-helper 2 cell differentiation GO:0045576 mast cell activation GO:0045580 regulation of T cell differentiation GO:0045581 negative regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045620 negative regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045622 regulation of T-helper cell differentiation GO:0045623 negative regulation of T-helper cell differentiation GO:0045624 positive regulation of T-helper cell differentiation GO:0045625 regulation of T-helper 1 cell differentiation GO:0045626 negative regulation of T-helper 1 cell differentiation GO:0045628 regulation of T-helper 2 cell differentiation GO:0045630 positive regulation of T-helper 2 cell differentiation GO:0045785 positive regulation of cell adhesion GO:0045921 positive regulation of exocytosis GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046636 negative regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0046639 negative regulation of alpha-beta T cell differentiation GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050777 negative regulation of immune response GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0051047 positive regulation of secretion GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:0060627 regulation of vesicle-mediated transport GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070670 response to interleukin-4 GO:0071353 cellular response to interleukin-4 GO:0071593 lymphocyte aggregation GO:0090195 chemokine secretion GO:0090196 regulation of chemokine secretion GO:0090197 positive regulation of chemokine secretion GO:0098542 defense response to other organism GO:1901739 regulation of myoblast fusion GO:1901741 positive regulation of myoblast fusion GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903305 regulation of regulated secretory pathway GO:1903307 positive regulation of regulated secretory pathway GO:1903532 positive regulation of secretion by cell GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904951 positive regulation of establishment of protein localization GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004913 interleukin-4 receptor activity GO:0005057 receptor signaling protein activity |
Cellular Component |
GO:0043235 receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL4R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL4R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL4R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL4R in various data sets.
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Points in the above scatter plot represent the mutation difference of IL4R in various data sets.
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Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL4R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL4R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL4R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL4R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL4R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL4R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL4R |
Name | interleukin 4 receptor |
Aliases | CD124; IL-4RAA; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain; CD ant ...... |
Chromosomal Location | 16p12.1-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL4R collected from DrugBank database. |
Details on drugs targeting IL4R.
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