Summary | |
---|---|
Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00489 Interleukin-6/G-CSF/MGF family |
Function |
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
Biological Process |
GO:0000060 protein import into nucleus, translocation GO:0000302 response to reactive oxygen species GO:0001101 response to acid chemical GO:0001503 ossification GO:0001525 angiogenesis GO:0001562 response to protozoan GO:0001649 osteoblast differentiation GO:0001763 morphogenesis of a branching structure GO:0001776 leukocyte homeostasis GO:0001780 neutrophil homeostasis GO:0001781 neutrophil apoptotic process GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001878 response to yeast GO:0001894 tissue homeostasis GO:0001933 negative regulation of protein phosphorylation GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002251 organ or tissue specific immune response GO:0002262 myeloid cell homeostasis GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002295 T-helper cell lineage commitment GO:0002360 T cell lineage commitment GO:0002363 alpha-beta T cell lineage commitment GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002369 T cell cytokine production GO:0002377 immunoglobulin production GO:0002384 hepatic immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002446 neutrophil mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002526 acute inflammatory response GO:0002548 monocyte chemotaxis GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002724 regulation of T cell cytokine production GO:0002726 positive regulation of T cell cytokine production GO:0002790 peptide secretion GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002828 regulation of type 2 immune response GO:0002830 positive regulation of type 2 immune response GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006109 regulation of carbohydrate metabolic process GO:0006111 regulation of gluconeogenesis GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006417 regulation of translation GO:0006469 negative regulation of protein kinase activity GO:0006606 protein import into nucleus GO:0006809 nitric oxide biosynthetic process GO:0006913 nucleocytoplasmic transport GO:0006925 inflammatory cell apoptotic process GO:0006953 acute-phase response GO:0006959 humoral immune response GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007262 STAT protein import into nucleus GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007517 muscle organ development GO:0007568 aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0008360 regulation of cell shape GO:0009266 response to temperature stimulus GO:0009306 protein secretion GO:0009408 response to heat GO:0009409 response to cold GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0009620 response to fungus GO:0009914 hormone transport GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010466 negative regulation of peptidase activity GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010608 posttranscriptional regulation of gene expression GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010677 negative regulation of cellular carbohydrate metabolic process GO:0010712 regulation of collagen metabolic process GO:0010713 negative regulation of collagen metabolic process GO:0010720 positive regulation of cell development GO:0010817 regulation of hormone levels GO:0010876 lipid localization GO:0010883 regulation of lipid storage GO:0010888 negative regulation of lipid storage GO:0010906 regulation of glucose metabolic process GO:0010951 negative regulation of endopeptidase activity GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0010996 response to auditory stimulus GO:0014074 response to purine-containing compound GO:0015833 peptide transport GO:0016049 cell growth GO:0016051 carbohydrate biosynthetic process GO:0017038 protein import GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0019226 transmission of nerve impulse GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0019915 lipid storage GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022410 circadian sleep/wake cycle process GO:0022604 regulation of cell morphogenesis GO:0022612 gland morphogenesis GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030098 lymphocyte differentiation GO:0030168 platelet activation GO:0030217 T cell differentiation GO:0030278 regulation of ossification GO:0030335 positive regulation of cell migration GO:0030431 sleep GO:0030595 leukocyte chemotaxis GO:0031000 response to caffeine GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031346 positive regulation of cell projection organization GO:0031349 positive regulation of defense response GO:0031644 regulation of neurological system process GO:0031646 positive regulation of neurological system process GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031960 response to corticosteroid GO:0032103 positive regulation of response to external stimulus GO:0032355 response to estradiol GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032494 response to peptidoglycan GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032635 interleukin-6 production GO:0032642 regulation of chemokine production GO:0032675 regulation of interleukin-6 production GO:0032682 negative regulation of chemokine production GO:0032722 positive regulation of chemokine production GO:0032755 positive regulation of interleukin-6 production GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032868 response to insulin GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032966 negative regulation of collagen biosynthetic process GO:0033002 muscle cell proliferation GO:0033028 myeloid cell apoptotic process GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033158 regulation of protein import into nucleus, translocation GO:0033160 positive regulation of protein import into nucleus, translocation GO:0033500 carbohydrate homeostasis GO:0033673 negative regulation of kinase activity GO:0034103 regulation of tissue remodeling GO:0034104 negative regulation of tissue remodeling GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034504 protein localization to nucleus GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0035270 endocrine system development GO:0035272 exocrine system development GO:0035637 multicellular organismal signaling GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0035743 CD4-positive, alpha-beta T cell cytokine production GO:0035745 T-helper 2 cell cytokine production GO:0040017 positive regulation of locomotion GO:0042033 chemokine biosynthetic process GO:0042035 regulation of cytokine biosynthetic process GO:0042036 negative regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042092 type 2 immune response GO:0042093 T-helper cell differentiation GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042107 cytokine metabolic process GO:0042110 T cell activation GO:0042113 B cell activation GO:0042129 regulation of T cell proliferation GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042391 regulation of membrane potential GO:0042493 response to drug GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042542 response to hydrogen peroxide GO:0042593 glucose homeostasis GO:0042742 defense response to bacterium GO:0042745 circadian sleep/wake cycle GO:0042748 circadian sleep/wake cycle, non-REM sleep GO:0042749 regulation of circadian sleep/wake cycle GO:0042752 regulation of circadian rhythm GO:0042832 defense response to protozoan GO:0042886 amide transport GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043200 response to amino acid GO:0043255 regulation of carbohydrate biosynthetic process GO:0043279 response to alkaloid GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043368 positive T cell selection GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043373 CD4-positive, alpha-beta T cell lineage commitment GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043491 protein kinase B signaling GO:0044057 regulation of system process GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044252 negative regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044708 single-organism behavior GO:0044723 single-organism carbohydrate metabolic process GO:0044744 protein targeting to nucleus GO:0045058 T cell selection GO:0045064 T-helper 2 cell differentiation GO:0045073 regulation of chemokine biosynthetic process GO:0045079 negative regulation of chemokine biosynthetic process GO:0045124 regulation of bone resorption GO:0045165 cell fate commitment GO:0045187 regulation of circadian sleep/wake cycle, sleep GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045444 fat cell differentiation GO:0045453 bone resorption GO:0045454 cell redox homeostasis GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045622 regulation of T-helper cell differentiation GO:0045624 positive regulation of T-helper cell differentiation GO:0045628 regulation of T-helper 2 cell differentiation GO:0045630 positive regulation of T-helper 2 cell differentiation GO:0045666 positive regulation of neuron differentiation GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045721 negative regulation of gluconeogenesis GO:0045727 positive regulation of translation GO:0045740 positive regulation of DNA replication GO:0045765 regulation of angiogenesis GO:0045778 positive regulation of ossification GO:0045779 negative regulation of bone resorption GO:0045785 positive regulation of cell adhesion GO:0045837 negative regulation of membrane potential GO:0045861 negative regulation of proteolysis GO:0045912 negative regulation of carbohydrate metabolic process GO:0046209 nitric oxide metabolic process GO:0046364 monosaccharide biosynthetic process GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0046677 response to antibiotic GO:0046716 muscle cell cellular homeostasis GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046851 negative regulation of bone remodeling GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0048305 immunoglobulin secretion GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0048514 blood vessel morphogenesis GO:0048545 response to steroid hormone GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048732 gland development GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050710 negative regulation of cytokine secretion GO:0050714 positive regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050755 chemokine metabolic process GO:0050769 positive regulation of neurogenesis GO:0050795 regulation of behavior GO:0050802 circadian sleep/wake cycle, sleep GO:0050817 coagulation GO:0050829 defense response to Gram-negative bacterium GO:0050830 defense response to Gram-positive bacterium GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051023 regulation of immunoglobulin secretion GO:0051024 positive regulation of immunoglobulin secretion GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051235 maintenance of location GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0051348 negative regulation of transferase activity GO:0051384 response to glucocorticoid GO:0051592 response to calcium ion GO:0051602 response to electrical stimulus GO:0051607 defense response to virus GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0051962 positive regulation of nervous system development GO:0051969 regulation of transmission of nerve impulse GO:0051971 positive regulation of transmission of nerve impulse GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060249 anatomical structure homeostasis GO:0060326 cell chemotaxis GO:0060445 branching involved in salivary gland morphogenesis GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0061138 morphogenesis of a branching epithelium GO:0070091 glucagon secretion GO:0070102 interleukin-6-mediated signaling pathway GO:0070301 cellular response to hydrogen peroxide GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070498 interleukin-1-mediated signaling pathway GO:0070555 response to interleukin-1 GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0070741 response to interleukin-6 GO:0070997 neuron death GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071347 cellular response to interleukin-1 GO:0071354 cellular response to interleukin-6 GO:0071356 cellular response to tumor necrosis factor GO:0071375 cellular response to peptide hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071548 response to dexamethasone GO:0071549 cellular response to dexamethasone stimulus GO:0071593 lymphocyte aggregation GO:0071674 mononuclear cell migration GO:0071838 cell proliferation in bone marrow GO:0071863 regulation of cell proliferation in bone marrow GO:0071864 positive regulation of cell proliferation in bone marrow GO:0071887 leukocyte apoptotic process GO:0072538 T-helper 17 type immune response GO:0072539 T-helper 17 cell differentiation GO:0072540 T-helper 17 cell lineage commitment GO:0072593 reactive oxygen species metabolic process GO:0090316 positive regulation of intracellular protein transport GO:0097050 type B pancreatic cell apoptotic process GO:0097529 myeloid leukocyte migration GO:0097696 STAT cascade GO:0098542 defense response to other organism GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901342 regulation of vasculature development GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902593 single-organism nuclear import GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903829 positive regulation of cellular protein localization GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904037 positive regulation of epithelial cell apoptotic process GO:1904407 positive regulation of nitric oxide metabolic process GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:1990637 response to prolactin GO:1990646 cellular response to prolactin GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000147 positive regulation of cell motility GO:2000364 regulation of STAT protein import into nucleus GO:2000366 positive regulation of STAT protein import into nucleus GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation GO:2000551 regulation of T-helper 2 cell cytokine production GO:2000553 positive regulation of T-helper 2 cell cytokine production GO:2000659 regulation of interleukin-1-mediated signaling pathway GO:2000660 negative regulation of interleukin-1-mediated signaling pathway GO:2000674 regulation of type B pancreatic cell apoptotic process GO:2000676 positive regulation of type B pancreatic cell apoptotic process GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005138 interleukin-6 receptor binding GO:0008083 growth factor activity GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0005896 interleukin-6 receptor complex GO:0009897 external side of plasma membrane GO:0043235 receptor complex GO:0098552 side of membrane GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage hsa04668 TNF signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-6783589: Interleukin-6 family signaling R-HSA-1059683: Interleukin-6 signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-112411: MAPK1 (ERK2) activation R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-110056: MAPK3 (ERK1) activation R-HSA-112409: RAF-independent MAPK1/3 activation R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL6 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL6 in various data sets.
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Points in the above scatter plot represent the mutation difference of IL6 in various data sets.
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Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL6 |
Name | interleukin 6 |
Aliases | IL-6; BSF2; HSF; interferon, beta 2; IFNB2; interleukin 6 (interferon, beta 2); B-cell differentiation facto ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL6 collected from DrugBank database. |
Details on drugs targeting IL6.
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