Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted. |
Domain |
PF00047 Immunoglobulin domain PF09240 Interleukin-6 receptor alpha chain |
Function |
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.; FUNCTION: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001819 positive regulation of cytokine production GO:0002251 organ or tissue specific immune response GO:0002384 hepatic immune response GO:0002526 acute inflammatory response GO:0002548 monocyte chemotaxis GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006953 acute-phase response GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030278 regulation of ossification GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0032103 positive regulation of response to external stimulus GO:0032602 chemokine production GO:0032635 interleukin-6 production GO:0032642 regulation of chemokine production GO:0032675 regulation of interleukin-6 production GO:0032722 positive regulation of chemokine production GO:0032755 positive regulation of interleukin-6 production GO:0033002 muscle cell proliferation GO:0035270 endocrine system development GO:0040017 positive regulation of locomotion GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042742 defense response to bacterium GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045778 positive regulation of ossification GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050829 defense response to Gram-negative bacterium GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0060326 cell chemotaxis GO:0070102 interleukin-6-mediated signaling pathway GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0070741 response to interleukin-6 GO:0071354 cellular response to interleukin-6 GO:0071674 mononuclear cell migration GO:0097191 extrinsic apoptotic signaling pathway GO:0097529 myeloid leukocyte migration GO:0097696 STAT cascade GO:0098542 defense response to other organism GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004897 ciliary neurotrophic factor receptor activity GO:0004915 interleukin-6 receptor activity GO:0005126 cytokine receptor binding GO:0005138 interleukin-6 receptor binding GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0019981 interleukin-6 binding GO:0070119 ciliary neurotrophic factor binding GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0005896 interleukin-6 receptor complex GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0043235 receptor complex GO:0045177 apical part of cell GO:0070110 ciliary neurotrophic factor receptor complex GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-6783589: Interleukin-6 family signaling R-HSA-1059683: Interleukin-6 signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-112411: MAPK1 (ERK2) activation R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-110056: MAPK3 (ERK1) activation R-HSA-112409: RAF-independent MAPK1/3 activation R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL6R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL6R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL6R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL6R in various data sets.
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Points in the above scatter plot represent the mutation difference of IL6R in various data sets.
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Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL6R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL6R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL6R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL6R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL6R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL6R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL6R |
Name | interleukin 6 receptor |
Aliases | CD126; IL-6R-1; IL-6RA; IL6QA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane gl ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL6R collected from DrugBank database. |
Details on drugs targeting IL6R.
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