Browse IL7R

Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 4: Secreted.
Domain PF00041 Fibronectin type III domain
Function

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

> Gene Ontology
 
Biological Process GO:0000018 regulation of DNA recombination
GO:0001906 cell killing
GO:0001909 leukocyte mediated cytotoxicity
GO:0001910 regulation of leukocyte mediated cytotoxicity
GO:0001911 negative regulation of leukocyte mediated cytotoxicity
GO:0001913 T cell mediated cytotoxicity
GO:0001914 regulation of T cell mediated cytotoxicity
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002377 immunoglobulin production
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002456 T cell mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002521 leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002698 negative regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002704 negative regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002707 negative regulation of lymphocyte mediated immunity
GO:0002709 regulation of T cell mediated immunity
GO:0002710 negative regulation of T cell mediated immunity
GO:0002819 regulation of adaptive immune response
GO:0002820 negative regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0006310 DNA recombination
GO:0007159 leukocyte cell-cell adhesion
GO:0008361 regulation of cell size
GO:0016049 cell growth
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0031341 regulation of cell killing
GO:0031342 negative regulation of cell killing
GO:0032535 regulation of cellular component size
GO:0032943 mononuclear cell proliferation
GO:0033077 T cell differentiation in thymus
GO:0033081 regulation of T cell differentiation in thymus
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045785 positive regulation of cell adhesion
GO:0046651 lymphocyte proliferation
GO:0048535 lymph node development
GO:0048872 homeostasis of number of cells
GO:0050777 negative regulation of immune response
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0051052 regulation of DNA metabolic process
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0090066 regulation of anatomical structure size
GO:0098760 response to interleukin-7
GO:0098761 cellular response to interleukin-7
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:2000398 regulation of thymocyte aggregation
GO:2000400 positive regulation of thymocyte aggregation
Molecular Function GO:0003823 antigen binding
GO:0004896 cytokine receptor activity
GO:0004917 interleukin-7 receptor activity
Cellular Component GO:0009897 external side of plasma membrane
GO:0098552 side of membrane
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
hsa04068 FoxO signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04640 Hematopoietic cell lineage
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-1266695: Interleukin-7 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IL7R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IL7R and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
16424053MelanomaPromote immunity (T cell function); essential for immunotherapyEfficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors. Importantly, the majority of anti-Melan-A T cells elicited by rec. lv expressed the memory marker CD127 at the peak of the primary response.
19471017Melanoma; FibrosarcomaPromote immunityWe skewed CD8(+) T cells to secrete IL-17 through priming in Th17-polarizing conditions. This improved antitumor immunity was associated with increased expression of IL-7R-alpha, decreased expression of killer cell lectin-like receptor G1, and enhanced persistence of the transferred cells.
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IL7R in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IL7R in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2930.491
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0770.944
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5610.494
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0610.907
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2870.86
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.230.916
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3680.581
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2820.843
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5010.742
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8230.343
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2280.324
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4180.0866
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IL7R in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 1417011.8-11.80.488
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.78.2-4.50.671
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.78.5-4.80.66
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.1023.10.223
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.311.1-5.80.642
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.515.4-10.90.541
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL7R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL7R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL7R.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL7R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IL7R expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IL7R and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIL7R
Nameinterleukin 7 receptor
Aliases CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ......
Chromosomal Location5p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IL7R collected from DrugBank database.
> Drugs from DrugBank database
 

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