Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 4: Secreted. |
Domain |
PF00041 Fibronectin type III domain |
Function |
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001911 negative regulation of leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0001914 regulation of T cell mediated cytotoxicity GO:0001915 negative regulation of T cell mediated cytotoxicity GO:0002250 adaptive immune response GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002707 negative regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002710 negative regulation of T cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0006310 DNA recombination GO:0007159 leukocyte cell-cell adhesion GO:0008361 regulation of cell size GO:0016049 cell growth GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0031341 regulation of cell killing GO:0031342 negative regulation of cell killing GO:0032535 regulation of cellular component size GO:0032943 mononuclear cell proliferation GO:0033077 T cell differentiation in thymus GO:0033081 regulation of T cell differentiation in thymus GO:0033089 positive regulation of T cell differentiation in thymus GO:0038111 interleukin-7-mediated signaling pathway GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0046651 lymphocyte proliferation GO:0048535 lymph node development GO:0048872 homeostasis of number of cells GO:0050777 negative regulation of immune response GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051052 regulation of DNA metabolic process GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0090066 regulation of anatomical structure size GO:0098760 response to interleukin-7 GO:0098761 cellular response to interleukin-7 GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000398 regulation of thymocyte aggregation GO:2000400 positive regulation of thymocyte aggregation |
Molecular Function |
GO:0003823 antigen binding GO:0004896 cytokine receptor activity GO:0004917 interleukin-7 receptor activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04068 FoxO signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-1266695: Interleukin-7 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL7R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL7R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL7R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL7R in various data sets.
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Points in the above scatter plot represent the mutation difference of IL7R in various data sets.
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Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL7R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL7R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL7R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL7R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL7R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL7R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IL7R |
Name | interleukin 7 receptor |
Aliases | CD127; CDW127; IL-7R-alphaA; ILRA; CD127 antigen; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; ...... |
Chromosomal Location | 5p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL7R collected from DrugBank database. |
There is no record. |