Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Secreted. |
Domain | - |
Function |
This is a receptor for interleukin-9. |
Biological Process |
GO:0001558 regulation of cell growth GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016049 cell growth GO:0030307 positive regulation of cell growth GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0038113 interleukin-9-mediated signaling pathway GO:0045927 positive regulation of growth GO:0051222 positive regulation of protein transport GO:0070585 protein localization to mitochondrion GO:0071104 response to interleukin-9 GO:0071355 cellular response to interleukin-9 GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004919 interleukin-9 receptor activity GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0019983 interleukin-9 binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL9R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL9R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL9R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL9R in various data sets.
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Points in the above scatter plot represent the mutation difference of IL9R in various data sets.
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Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL9R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL9R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL9R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL9R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL9R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL9R |
Name | interleukin 9 receptor |
Aliases | CD129; IL-9R; IL-9 receptor; CD antigen CD129; Interleukin-9 receptor |
Chromosomal Location | Xq28 and Yq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL9R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |