Summary | |
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Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type I membrane protein |
Domain |
PF05624 Lipolysis stimulated receptor (LSR) |
Function |
May be involved in lipid homeostasis and ER stress pathways. |
Biological Process |
GO:0001894 tissue homeostasis GO:0002790 peptide secretion GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0031016 pancreas development GO:0034284 response to monosaccharide GO:0042886 amide transport GO:0046879 hormone secretion GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048873 homeostasis of number of cells within a tissue GO:0060249 anatomical structure homeostasis |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ILDR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ILDR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ILDR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ILDR2 in various data sets.
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Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ILDR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ILDR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ILDR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ILDR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ILDR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ILDR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ILDR2 |
Name | immunoglobulin-like domain containing receptor 2 |
Aliases | LISCH-like; C1orf32; chromosome 1 open reading frame 32; dJ782G3.1; Immunoglobulin-like domain-containing re ...... |
Chromosomal Location | 1q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ILDR2 collected from DrugBank database. |
There is no record. |