Browse ILK

Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell junction, focal adhesion Cell membrane; Peripheral membrane protein; Cytoplasmic side Cell projection, lamellipodium Cytoplasm, myofibril, sarcomere
Domain PF12796 Ankyrin repeats (3 copies)
PF07714 Protein tyrosine kinase
Function

Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001667 ameboidal-type cell migration
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001933 negative regulation of protein phosphorylation
GO:0001952 regulation of cell-matrix adhesion
GO:0001954 positive regulation of cell-matrix adhesion
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0006469 negative regulation of protein kinase activity
GO:0007050 cell cycle arrest
GO:0007160 cell-matrix adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007272 ensheathment of neurons
GO:0007409 axonogenesis
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007568 aging
GO:0007569 cell aging
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008361 regulation of cell size
GO:0008366 axon ensheathment
GO:0010001 glial cell differentiation
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010657 muscle cell apoptotic process
GO:0010658 striated muscle cell apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0010660 regulation of muscle cell apoptotic process
GO:0010662 regulation of striated muscle cell apoptotic process
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010665 regulation of cardiac muscle cell apoptotic process
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010720 positive regulation of cell development
GO:0010761 fibroblast migration
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010927 cellular component assembly involved in morphogenesis
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014037 Schwann cell differentiation
GO:0014044 Schwann cell development
GO:0014812 muscle cell migration
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0016358 dendrite development
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0021675 nerve development
GO:0021782 glial cell development
GO:0022011 myelination in peripheral nervous system
GO:0022604 regulation of cell morphogenesis
GO:0030111 regulation of Wnt signaling pathway
GO:0030168 platelet activation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030278 regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030516 regulation of axon extension
GO:0031346 positive regulation of cell projection organization
GO:0031589 cell-substrate adhesion
GO:0032288 myelin assembly
GO:0032292 peripheral nervous system axon ensheathment
GO:0032535 regulation of cellular component size
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033002 muscle cell proliferation
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034109 homotypic cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035239 tube morphogenesis
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0042063 gliogenesis
GO:0042326 negative regulation of phosphorylation
GO:0042552 myelination
GO:0042692 muscle cell differentiation
GO:0043062 extracellular structure organization
GO:0043206 extracellular fibril organization
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043491 protein kinase B signaling
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045445 myoblast differentiation
GO:0045661 regulation of myoblast differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045773 positive regulation of axon extension
GO:0045778 positive regulation of ossification
GO:0045785 positive regulation of cell adhesion
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045927 positive regulation of growth
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050773 regulation of dendrite development
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051259 protein oligomerization
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051291 protein heterooligomerization
GO:0051348 negative regulation of transferase activity
GO:0051402 neuron apoptotic process
GO:0051493 regulation of cytoskeleton organization
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051962 positive regulation of nervous system development
GO:0060070 canonical Wnt signaling pathway
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060993 kidney morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0070527 platelet aggregation
GO:0070997 neuron death
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0090066 regulation of anatomical structure size
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0097435 fibril organization
GO:0198738 cell-cell signaling by wnt
GO:1900006 positive regulation of dendrite development
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1990138 neuron projection extension
GO:2000146 negative regulation of cell motility
GO:2000147 positive regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0005178 integrin binding
GO:0017124 SH3 domain binding
GO:0050839 cell adhesion molecule binding
Cellular Component GO:0001725 stress fiber
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030027 lamellipodium
GO:0030055 cell-substrate junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031252 cell leading edge
GO:0032432 actin filament bundle
GO:0033267 axon part
GO:0042641 actomyosin
GO:0043025 neuronal cell body
GO:0043034 costamere
GO:0043195 terminal bouton
GO:0043198 dendritic shaft
GO:0043292 contractile fiber
GO:0043679 axon terminus
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0044449 contractile fiber part
GO:0097517 contractile actin filament bundle
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG hsa03320 PPAR signaling pathway
hsa04360 Axon guidance
hsa04510 Focal adhesion
Reactome R-HSA-446728: Cell junction organization
R-HSA-1500931: Cell-Cell communication
R-HSA-446353: Cell-extracellular matrix interactions
R-HSA-446343: Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ILK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ILK and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26921343Lung CarcinomaPromote immunity (infiltration, T cell function)Here, we used viable human lung tumor slices and autologous tumor antigen-specific T-lymphocyte clones to provide evidence that CD103 is directly involved in T-lymphocyte recruitment within epithelial tumor islets and intratumoral early T-cell signaling. Mechanistic investigations revealed that TGFβ bound to its receptors (TGFBR), which promoted the recruitment and phosphorylation of integrin-linked kinase (ILK) by TGFBR1. We further show that ILK interacted with the CD103 intracellular domain, resulting in protein kinase B (PKB)/AKT activation, thereby initiating integrin inside-out signaling.
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ILK in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.62; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ILK in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1090.6
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3210.908
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4210.832
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2520.769
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2340.916
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8730.764
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0380.928
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2340.902
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3370.873
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3220.887
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8280.807
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1730.0274
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ILK in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ILK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ILK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ILK.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ILK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ILK expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ILK and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolILK
Nameintegrin-linked kinase
Aliases HEL-S-28-1; ILK-2; p59ILK; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integ ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ILK collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.