Summary | |
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Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF15142 INCA1 |
Function |
- |
Biological Process |
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0033673 negative regulation of kinase activity GO:0042326 negative regulation of phosphorylation GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045786 negative regulation of cell cycle GO:0051348 negative regulation of transferase activity GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904030 negative regulation of cyclin-dependent protein kinase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019207 kinase regulator activity GO:0019210 kinase inhibitor activity GO:0019887 protein kinase regulator activity GO:0030291 protein serine/threonine kinase inhibitor activity GO:0030332 cyclin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between INCA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of INCA1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of INCA1 in various data sets.
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Points in the above scatter plot represent the mutation difference of INCA1 in various data sets.
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Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INCA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INCA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INCA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INCA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of INCA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between INCA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | INCA1 |
Name | inhibitor of CDK, cyclin A1 interacting protein 1 |
Aliases | HSD45; Inhibitor of CDK interacting with cyclin A1; Protein INCA1 |
Chromosomal Location | 17p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting INCA1 collected from DrugBank database. |
There is no record. |