Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome, centromere Cytoplasm, cytoskeleton, spindle Midbody Chromosome, centromere, kinetochore Note=Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes to inner kinetochore (PubMed:16760428). Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:15316025). Cocalizes to the equatorial cell cortex at anaphase (PubMed:11453556). |
Domain |
PF03941 Inner centromere protein PF12178 Chromosome passenger complex (CPC) protein INCENP N terminal |
Function |
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). |
Biological Process |
GO:0000819 sister chromatid segregation GO:0000910 cytokinesis GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0098813 nuclear chromosome segregation |
Molecular Function | - |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000785 chromatin GO:0000792 heterochromatin GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000795 synaptonemal complex GO:0000800 lateral element GO:0000801 central element GO:0005721 pericentric heterochromatin GO:0005819 spindle GO:0005874 microtubule GO:0010369 chromocenter GO:0030496 midbody GO:0044454 nuclear chromosome part GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-68886: M Phase R-HSA-392499: Metabolism of proteins R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-597592: Post-translational protein modification R-HSA-195258: RHO GTPase Effectors R-HSA-5663220: RHO GTPases Activate Formins R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-4615885: SUMOylation of DNA replication proteins R-HSA-2467813: Separation of Sister Chromatids R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between INCENP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of INCENP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of INCENP in various data sets.
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Points in the above scatter plot represent the mutation difference of INCENP in various data sets.
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Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INCENP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INCENP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INCENP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INCENP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of INCENP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between INCENP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | INCENP |
Name | inner centromere protein antigens 135/155kDa |
Aliases | FLJ31633; inner centromere protein antigens (135kD, 155kD); binds and activates aurora-B and -C in vivo and ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting INCENP collected from DrugBank database. |
Details on drugs targeting INCENP.
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