Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00019 Transforming growth factor beta like domain |
Function |
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
Biological Process |
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO:0060395 SMAD protein signal transduction GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005160 transforming growth factor beta receptor binding GO:0005179 hormone activity GO:0008083 growth factor activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04350 TGF-beta signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-209822: Glycoprotein hormones R-HSA-392499: Metabolism of proteins R-HSA-209952: Peptide hormone biosynthesis R-HSA-2980736: Peptide hormone metabolism |
Summary | |
---|---|
Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between INHBE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between INHBE and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of INHBE in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of INHBE in various data sets.
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Points in the above scatter plot represent the mutation difference of INHBE in various data sets.
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Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INHBE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INHBE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INHBE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INHBE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of INHBE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | INHBE |
Name | inhibin, beta E |
Aliases | activin; MGC4638; activin beta E; activin beta-E chain; Inhibin beta E chain |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between INHBE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |